Evidence map›Paper›PMID 33190198›Full record

ArticleThe international journal of cardiovascular imaging2021

Use of the new Lake Louise Criteria improves CMR detection of atypical forms of acute myocarditis.

Giulia Cundari, Nicola Galea, Gianluca De Rubeis, Andrea Frustaci, Francesco Cilia, Giuseppe Mancuso, Livia Marchitelli, Federica Catapano, Iacopo Carbone, Carlo Catalano and 1 more

Abstract readComparative Study
In one paragraph

Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Cardiac Involvement in Systemic Lupus Erythematosus.Reviews in cardiovascular medicine · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
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  14. Article
  15. The value of dual-energy computed tomography in the evaluation of myocarditisDiagnostic and interventional radiology (Ankara, Turkey) · 2023
    Article
  16. Review
  17. Article
  18. Review
  19. Comparing the findings and diagnostic sensitivity of cardiovascular magnetic resonance in biopsy confirmed acute myocarditis with infarct-like vs. heart failure presentation.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giulia CundariDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy. giulia.cundari@uniroma1.it.ORCID http://orcid.org/0000-0003-3867-3211
Nicola GaleaDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Gianluca De RubeisDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Andrea FrustaciDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Francesco CiliaDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Giuseppe MancusoDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Livia MarchitelliDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Federica CatapanoDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Iacopo CarboneDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Carlo CatalanoDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.
Marco FranconeDepartment of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of our study was to compare diagnostic performance of old and new Lake Louise Criteria (oLLC and nLLC) among different clinical presentations: infarct-like (IL), cardiomyopathic (CM) and arrhythmic (AR). 102 patients with clinical suspicion of acute myocarditis underwent cardiac magnetic resonance (CMR) on a 1.5 T scanner. Protocol included cine-SSFP, T2-weighted STIR, T2 mapping, early and late gadolinium enhancement and T1 mapping acquired before and after gadolinium administration. The degree of agreement has been calculated with Cohen's K test. 42 patients also underwent endomyocardial biopsy (EMB). IL onset was present in 54/102 patients, CM in 28/102 and AR in 20/102. nLLC were positive in 58.3% of the patients, while oLLC in 37.9%, k = 0.57 (IC: 0.428-0.713). The degree of agreement between nLLC and oLLC was 0.49 (IC: 0.111-0.876) for AR onset (nLLC positive in 35% vs oLLC in 15%), 0.25 (IC: 0.035-0.459) for CM pattern (nLLC positive in 60.7% vs oLLC 17.9%) and 0.73 (IC: 0.543-0.912) for IL presentation (nLLC positive in 66.7% vs oLLC in 57.4%). Diagnostic accuracy was 75% for both nLLC and oLLC among IL onset, and 41.6% for oLLC vs 66.7% for nLLC, as regards CM clinical presentation. nLLC have improved diagnostic performance of CMR for the diagnosis of acute myocarditis, in particular for atypical clinical presentation.

Indexed as

Decision Support TechniquesMagnetic Resonance Imaging, CineAcute DiseaseAdultContrast MediaFemaleHeterocyclic CompoundsHumansMaleMiddle AgedMyocarditisOrganometallic CompoundsPredictive Value of TestsPrognosisReproducibility of ResultsRetrospective StudiesContrast Mediagadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetateHeterocyclic CompoundsOrganometallic CompoundsAgreementAtypical onsetsDiagnostic accuracyLake Louise criteriaMyocarditis

Identifiers

PMID33190198
PMCPMC8026431

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.