Effects of Omega-3 Fatty Acids on Major Adverse Cardiovascular Events: What Matters Most: the Drug, the Dose, or the Placebo?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

1. Accuracy of Machine Learning Models for Early Prediction of Major Cardiovascular Events Post Myocardial Infarction: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025
   Pooled it
2. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials.Frontiers in nutrition · 2024
   Pooled it
3. Effects of ω-3 Polyunsaturated Fatty Acids on Coronary Atherosclerosis and Inflammation: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022
   Pooled it
4. Icosapent ethyl for reduction in cardiovascular disease risk in adults with hypertriglyceridaemia.Australian prescriber · 2024
   Review
5. Carnitine O-octanoyltransferase (CROT) deficiency in mice leads to an increase of omega-3 fatty acids.Frontiers in molecular biosciences · 2024
   Article
6. Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study.Frontiers in nutrition · 2023
   Article
7. Controversies in the Use of Omega-3 Fatty Acids to Prevent Atherosclerosis.Current atherosclerosis reports · 2022
   Review
8. Role of omega-3 fatty acids in the prevention and treatment of cardiovascular Diseases: A consensus statement from the Experts' Committee Of National Society Of Cardiometabolic Medicine.Frontiers in pharmacology · 2022
   Review
9. Cardioprotective Effects of Nutraceuticals: Focus on Omega-3 Polyunsaturated Fatty Acids.Nutrients · 2021
   Article
10. Intersection Between Chronic Kidney Disease and Cardiovascular Disease.Current cardiology reports · 2021
    Review
11. Icosapent ethyl: scientific and legal controversies.Open heart · 2021
    Review
12. Triglyceride lowering by omega-3 fatty acids: a mechanism mediated by N-acyl taurines.The Journal of clinical investigation · 2021
    Article
13. Lipid Lowering Drugs: Present Status and Future Developments.Current atherosclerosis reports · 2021
    Review
14. Fatty Acids and Cardiovascular Risk. Evidence, Lack of Evidence, and Diligence.Nutrients · 2020
    Review
15. Omega-3 fatty acids for cardiovascular disease prevention: A practice tool for pharmacists.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
16. Fish Oil Supplements for Prevention of Cardiovascular Disease: The Jury Is Still Out: CON: Fish Oil is Useful to Prevent or Treat Cardiovascular Disease.Missouri medicine
    Article

Corrections and comments

• Comment on
  Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial.2020

Authors and funding

3 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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