Evidence map›Paper›PMID 33190118›Full record

ArticleJournal of affective disorders2021

Subjective response to alcohol: Associated alcohol use and orbitofrontal gray matter volume in bipolar disorder.

Valeria Tretyak, Dylan E Kirsch, Sepeadeh Radpour, Wade A Weber, Kim Fromme, Stephen M Strakowski, Elizabeth T C Lippard

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Valeria TretyakDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA; Department of Psychology, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA.
Dylan E KirschDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Institute for Neuroscience, University of Texas, Austin, TX, USA.
Sepeadeh RadpourDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA.
Wade A WeberDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA.
Kim FrommeDepartment of Psychology, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA.
Stephen M StrakowskiDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA; Department of Psychology, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Institute for Neuroscience, University of Texas, Austin, TX, USA.
Elizabeth T C LippardDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA; Department of Psychology, University of Texas, Austin, TX, USA; Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA; Institute for Neuroscience, University of Texas, Austin, TX, USA; Institute of Early Life Adversity Research, University of Texas, Austin, TX, USA. Electronic address: elizabeth.lippard@austin.utexas.edu.
The University of Texas at Austin · US

Funding

Neurochemical & Behavioral Correlates of ETOH EffectsT32AA007471 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI Kimberly Nixon · 1987 to 2026
$9.2M
Genetic Mechanisms of Change in Trajectories of Drinking and Deviant BehaviorsR01AA020637 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI FROMME, KIM · 2012 to 2016
$2.3M
Subjective Response to Alcohol and Associated Neural Systems in Bipolar DisorderK01AA027573 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI LIPPARD, ELIZABETH THOMAS COX · 2019 to 2022
$716k
NIAAA NIH HHS K01 AA027573NIAAA NIH HHS R01 AA020637NIAAA NIH HHS T32 AA007471
6 · The paper itself

Abstract

backgroundAlcohol use disorders (AUDs) are highly prevalent in bipolar disorder, however the developmental etiology of this comorbidity remains unknown. Structural differences in the orbitofrontal cortex (OFC) have been linked to problematic drinking in bipolar disorder and typically developing youth, with evidence implicating variations in OFC in differential subjective response to alcohol in typical development.

methodsSubjective response to alcohol, recent alcohol use, impulsivity, and variation in OFC gray matter volume were investigated in 48 emerging adults (24 with bipolar disorder, 24 typically developing). On average 1.5 years later, drinking patterns were reassessed and relations between subjective response and changes in alcohol use were explored.

resultsGroups did not differ in baseline alcohol use or subjective response. At baseline, decreased subjective response to alcohol was associated with increased alcohol use in both groups. Lower gray matter volume in medial OFC in bipolar disorder was associated with increased subjective response to alcohol, whereas lower gray matter volume in OFC in typically developing participants was associated with decreased subjective response to alcohol. Increase in alcohol use (baseline to follow-up) was associated with increased baseline subjective response to alcohol in bipolar disorder, and decreased baseline subjective response in the typically developing group. LIMITATIONS: Preliminary study with a small sample size.

conclusionUnderlying OFC biology may contribute to differences in alcohol sensitivity in bipolar disorder which may also relate to prospective changes in alcohol use patterns. Future studies are needed to examine how these factors prospectively relate to development of AUDs in bipolar disorder.

Indexed as

AlcoholismBipolar DisorderAdolescentAdultGray MatterHumansMagnetic Resonance ImagingPrefrontal CortexProspective Studiesalcohol drinkingbipolar disorderprefrontal cortex

Identifiers

PMID33190118
PMCPMC7812664
OpenAlexW3094955826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.