Evidence map›Paper›PMID 33190111›Full record

ArticleJournal of affective disorders2021

Suicide risk in people with post-traumatic stress disorder: A cohort study of 3.1 million people in Sweden.

Verity Fox, Christina Dalman, Henrik Dal, Anna-Clara Hollander, James B Kirkbride, Alexandra Pitman

Open access · hybridAbstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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  6. A living systematic review, meta-analysis, and open data resource of trials of MDMA-assisted therapy for PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  10. Low 5HTJournal of neurochemistry · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Verity FoxDivision of Psychiatry, UCL, London, W1T 7NF, United Kingdom.
Christina DalmanDepartment of Global Public Health, Karolinska Institutet, Sweden; Centre for Epidemiology and Social Medicine, The Region Stockholm, Sweden.
Henrik DalDepartment of Global Public Health, Karolinska Institutet, Sweden.
Anna-Clara HollanderDepartment of Global Public Health, Karolinska Institutet, Sweden.
James B KirkbrideDivision of Psychiatry, UCL, London, W1T 7NF, United Kingdom.
Alexandra PitmanDivision of Psychiatry, UCL, London, W1T 7NF, United Kingdom; Camden and Islington NHS Foundation Trust, London, NW1 0PE, United Kingdom. Electronic address: a.pitman@ucl.ac.uk.
Karolinska Institutet · SEUniversity College London · GB

Funding

Medical Research Council G0802441Wellcome Trust
6 · The paper itself

Abstract

backgroundIt is unclear whether post-traumatic stress disorder [PTSD] is associated with suicide risk in the general population, whether this differs by sex, or what the population impact of PTSD is for suicide.

methodsWe constructed a nationwide cohort of all people living in Sweden, born 1973-1997, followed from their 14th birthday (or immigration, if later) until suicide, other death, emigration or 31 December 2016. We used Cox proportional hazards regression to estimate hazard ratios [HR], and calculated the population impact of PTSD on suicide. We included sensitivity analyses to explore effects of outcome and exposure definitions, and to account for potential competing risks.

resultsOf 3,177,706 participants, 22,361 (0•7%) were diagnosed with PTSD, and 6,319 (0•2%) died by suicide over 49•2 million person-years. Compared with women and men without PTSD, suicide rates were 6•74 (95%CI: 5•61-8•09) and 3•96 (95%CI: 3•12-5•03) times higher in those with PTSD, respectively, after sociodemographic adjustment. Suicide rates remained elevated in women (HR: 2•61; 95%CI: 2•16-3•14) and men (HR: 1•67; 95%CI: 1•31-2•12) after adjustment for previous psychiatric conditions; attenuation was driven by previous non-fatal suicide attempts. Findings were insensitive to definitions or competing risks. If causal, 1•6% (95%CI: 1•2-2•1) of general population suicides could be attributed to PTSD, and up to 53.7% (95%CI: 46.1-60.2) in people with PTSD. LIMITATIONS: Residual confounding remains possible due to depressive and anxiety disorders diagnosed in primary care but unrecorded in these registers.

conclusionsClinical guidelines for the management of people with PTSD should recognise increased suicide risks.

Indexed as

Stress Disorders, Post-TraumaticCohort StudiesEmigration and ImmigrationFemaleHumansMaleRisk FactorsSwedenCohort studyEpidemiologyPost-traumatic stress disorderPTSDSuicide

Identifiers

PMID33190111
PMCPMC7758737
OpenAlexW3092030361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.