ArticleVision research2021
Orientation-specific long-term neural adaptation of the visual system in keratoconus.
Article in Vision research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Impact of contact lens correction on wavefront aberrations and vision quality in keratoconus.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Review
- Neural contrast sensitivity is not affected by myopic blur.Scientific reports · 2025Article
- Comparison of Unaided and Aided Visual Acuity in Adults With Down Syndrome.Translational vision science & technology · 2025Article
- Non-orthogonal spectacle correction for irregular astigmatism.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Neural adaptation to the eye's optics through phase compensation.bioRxiv : the preprint server for biology · 2024Article
- Utilising a visual image quality metric to optimise spectacle prescriptions for eyes with keratoconus.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Effects of Lens-Induced Astigmatism at Near and Far Distances.Clinical optometry · 2023Article
- Suprathreshold Contrast Perception Is Altered by Long-term Adaptation to Habitual Optical Blur.Investigative ophthalmology & visual science · 2022Article
- Automatic compensation enhances the orientation perception in chronic astigmatism.Scientific reports · 2022Article
- Clinical applications of personalising the neural components of visual image quality metrics for individual eyes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Article
- Effect of Spectacle Lenses with Highly Aspherical Lenslets on Binocular Vision and Accommodation in Myopic Children with and without Intermittent Exotropia.Journal of ophthalmology · 2022Article
- Modeling refractive correction strategies in keratoconus.Journal of vision · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Eyes with the corneal ectasia keratoconus have performed better than expected (e.g. visual acuity) given their elevated levels of higher-order aberrations that cause rotationally asymmetric retinal blur. Adapted neural processing has been suggested as an explanation but has not been measured across multiple meridional orientations. Using a custom Maxwellian-view laser interferometer to bypass ocular optics, sinusoidal grating neural contrast sensitivity was measured in six eyes (three subjects) with keratoconus and four typical eyes (two subjects) at six spatial frequencies and eight orientations using a two-interval forced-choice paradigm. Total measurement duration was 24 to 28 hours per subject. Neural contrast sensitivity functions of typical eyes agreed with literature and generally showed the oblique effect on a linear-scale and rotational symmetry on a log-scale (rotational symmetry was quantified as the ratio of the minor and major radii of an ellipse fit to all orientations within each spatial frequency; typical eye mean 0.93, median 0.93; where a circle = 1). Mean sensitivities of eyes with keratoconus were 20% to 60% lower (at lower and higher spatial frequencies respectively) than typical eyes. Orientation-specific neural contrast sensitivity functions in keratoconus showed substantial rotational asymmetry (ellipse radii ratio: mean 0.84; median 0.86) and large meridional reductions. The visual image quality metric VSX was used with a permutation test to combine the asymmetric optical aberrations of the eyes with keratoconus and their measured asymmetric neural functions, which illustrated how the neural sensitivities generally mitigated the detrimental effects of the optics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.