ArticlePediatric neurology2021
Intracranial and Extracranial Vascular Stenosis as Risk Factors for Stroke in Sickle Cell Disease.
Article in Pediatric neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Cerebral Blood Transit in Sickle Cell Anemia.Journal of magnetic resonance imaging : JMRI · 2026Article
- Observational
- Genetic and epigenetic architectures of stroke: Insights from GWAS to precision medicine.Neurochemistry international · 2025Review
- Cerebral Oxygen Metabolic Stress in Children and Adults With Large Vessel Vasculopathy Due to Sickle Cell Disease.Neurology · 2024Article
- Efficacy of butylphthalide in the treatment of patients with stroke attributed to intracranial arterial stenosis.Pakistan journal of medical sciences · 2024Article
- Red cell exchange transfusions increase cerebral capillary transit times and may alter oxygen extraction in sickle cell disease.NMR in biomedicine · 2023Article
- Association of laboratory markers and cerebral blood flow among sickle cell anemia children.Frontiers in pediatrics · 2022Article
- Incidence, kinetics, and risk factors for intra- and extracranial cerebral arteriopathies in a newborn sickle cell disease cohort early assessed by transcranial and cervical color Doppler ultrasound.Frontiers in neurology · 2022Article
- Quantitative susceptibility mapping (QSM) and R2Frontiers in neurology · 2022Article
- Association Between Serum Uric Acid and Intracranial Arterial Stenosis in a Korean Population: A Secondary Analysis Based on a Cross-Sectional Study.Frontiers in neurology · 2022Article
- Progression of central nervous system disease from pediatric to young adulthood in sickle cell anemia.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Epidemiology of Stroke in Sickle Cell Disease.Journal of clinical medicine · 2021Review
- Safety of 3 Tesla Magnetic Resonance Imaging in Patients with Sickle Cell Disease.Radiology research and practice · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevalence and contribution of intracranial and extracranial arterial stenosis to stroke risk were assessed prospectively in children and young adults with sickle cell disease.
methodsIn this cross-sectional study, children and young adults (mean = 19.4 years) with sickle cell disease underwent neurological examination, brain MRI, and magnetic resonance angiography of the head and neck. Two neuroradiologists independently recorded infarcts and arterial stenosis. Clinical features and stroke outcomes were compared between participants with and without stenosis and between children and young adults. Logistic regression analysis assessed the association of variables of interest with overt stroke and silent cerebral infarct.
resultsOf 167 participants (79 children and 88 young adults), 20 (12.0%) had intracranial stenosis, all in the anterior circulation, and nine had concurrent extracranial stenosis. No participants had isolated extracranial stenosis. Participants with intracranial stenosis were more likely than those without stenosis to have an overt stroke (70% vs 5%, P < 0.001) or silent cerebral infarct (95% vs 35%, P < 0.001). Logistic regression analysis indicated that intracranial stenosis was strongly associated with overt stroke when compared with participants with silent cerebral infarct alone and strongly associated with silent cerebral infarct when compared with participants with normal brain MRI; male sex and age were also significant predictors of silent cerebral infarct.
conclusionsIntracranial stenosis was strongly associated with both overt stroke and silent cerebral infarct; prevalence of intracranial stenosis was similar to prior estimates in sickle cell disease. Extracranial stenosis without concurrent intracranial stenosis did not occur and thus could not be evaluated as an independent risk factor for stroke.
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