Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2021
Personalized Depression Prevention: A Randomized Controlled Trial to Optimize Effects Through Risk-Informed Personalization.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01948167 (Bending Adolescent Depression Trajectories Through Personalized Prevention), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bending Adolescent Depression Trajectories Through Personalized Prevention
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Next-Generation Cognitive-Behavioral Therapy for Depression: Integrating Digital Tools, Teletherapy, and Personalization for Enhanced Mental Health Outcomes.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Scoping review of precision child and youth mental health research: dwelling in possibility.Frontiers in psychiatry · 2025Pooled it
- Trial
- Cognitive and interpersonal moderators of two evidence-based depression prevention programs.Journal of consulting and clinical psychology · 2024Trial
- Effects of personalized depression prevention on anxiety through 18-month follow-up: A randomized controlled trial.Behaviour research and therapy · 2022Trial
- Personalized Depression Prevention Reduces Dependent Stressors Among Adolescents: Results from a Randomized Controlled Trial.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Advancing in Personalization of Psychological, Indicated Preventive Interventions: A Randomized Controlled Trial in Adolescents at High-Risk of Developing Emotional Disorders.Child psychiatry and human development · 2026Article
- From profiles to precision: incorporating the Psychosocial Assessment Tool (PAT) and the Strengths and Difficulties Questionnaire (SDQ) to inform treatment planning in outpatient psychiatry.European child & adolescent psychiatry · 2026Article
- Do all adolescents benefit equally from school-based mental health interventions? A subgroup analysis by depression severity at 12 and 18 months follow-up.Frontiers in psychiatry · 2026Article
- Temporal Orientation and the Association Between Adverse Life Events and Internalizing Symptoms in Vietnamese American and European American Adolescents.Child psychiatry and human development · 2025Article
- Risk prediction models for depression in older adults with cancer.BMC psychiatry · 2025Article
- Trajectories of Rumination and Negative Cognitive Style from Late Childhood Through Adolescence: Modeling Normative Growth Patterns and Predicting Cognitive Vulnerabilities.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- What CBT Modules Work Best for Whom? Identifying Subgroups of Depressed Youths by Their Differential Response to Specific Modules.Behavior therapy · 2024Article
- The efficacy of personalized psychological interventions in adolescents: a scoping review and meta-analysis.Frontiers in psychology · 2024Article
- What Do We Know About Depression Among Youth and How Can We Make Progress Toward Improved Understanding and Reducing Distress? A New Hope.Clinical child and family psychology review · 2023Review
- Research Review: The internalizing paradox - youth anxiety and depression symptoms, psychotherapy outcomes, and implications for research and practice.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
- Do specific modules of cognitive behavioral therapy for depression have measurable effects on youth internalizing symptoms? An idiographic analysis.Psychotherapy research : journal of the Society for Psychotherapy Research · 2023Article
- Social Support and Parental Conflict as Predictors of Outcomes of Group Cognitive Behavioral Therapy for Adolescent Depression.International journal of cognitive therapy · 2023Article
- Stage models for major depression: Cognitive behavior therapy, mechanistic treatment targets, and the prevention of stage transition.Clinical psychology review · 2022Review
- The Potential for Outdoor Nature-Based Interventions in the Treatment and Prevention of Depression.Frontiers in psychology · 2022Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate whether evidence-based depression prevention programs can be optimized by matching youths to interventions that address their psychosocial vulnerabilities.
methodThis randomized controlled trial included 204 adolescents (mean [SD] age = 14.26 [1.65] years; 56.4% female). Youths were categorized as high or low on cognitive and interpersonal risks for depression and randomly assigned to Coping With Stress (CWS), a cognitive-behavioral program, or Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), an interpersonal program. Some participants received a match between risk and prevention (eg, high cognitive-low interpersonal risk teen in CWS, low cognitive-high interpersonal risk teen in IPT-AST), others received a mismatch (eg, low cognitive-high interpersonal risk teen in CWS). Outcomes were depression diagnoses and symptoms through 18 months postintervention (21 months total).
resultsMatched adolescents showed significantly greater decreases in depressive symptoms than mismatched adolescents from postintervention through 18-month follow-up and across the entire 21-month study period (effect size [d] = 0.44, 95% CI = 0.02, 0.86). There was no significant difference in rates of depressive disorders among matched adolescents compared with mismatched adolescents (12.0% versus 18.3%, t
conclusionThis study illustrates one approach to personalizing depression prevention as a form of precision mental health. Findings suggest that risk-informed personalization may enhance effects beyond a one-size-fits-all approach. CLINICAL TRIAL REGISTRATION INFORMATION: Bending Adolescent Depression Trajectories Through Personalized Prevention; https://www.clinicaltrials.gov/; NCT01948167.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.