Evidence map›Paper›PMID 33189566›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2021

The liver transplant risk score prognosticates the outcomes of liver transplant recipients at listing.

Christof Kaltenmeier, Dana Jorgensen, Stalin Dharmayan, Subhashini Ayloo, Vikrant Rachakonda, David A Geller, Samer Tohme, Michele Molinari

Open access · bronzeAbstract read
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  11. The BAR Score Predicts and Stratifies Outcomes Following Liver Retransplantation: Insights From a Retrospective Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christof KaltenmeierDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Dana JorgensenDepartment of Surgery (Statistics), University of Pittsburgh, Pittsburgh, PA, USA.
Stalin DharmayanDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Subhashini AylooDepartment of Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.
Vikrant RachakondaDepartment of Medicine, University of Pittsburg, Pittsburgh, PA, USA.
David A GellerDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Samer TohmeDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Michele MolinariDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: molinarim@upmc.edu.
University of Pittsburgh · USPittsburg State University · USRutgers New Jersey Medical School

Funding

Postdoctoral Research Training in Biotherapy of CancerT32CA113263 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Udai S Kammula · 2006 to 2026
$3.6M
NCI NIH HHS T32 CA113263
6 · The paper itself

Abstract

backgroundWe assessed if the risk of post-liver transplant mortality within 24 h could be stratified at the time of listing using the liver transplant risk score (LTRS). Secondary aims were to assess if the LTRS could stratify the risk of 30-day, 1-year mortality, and survival beyond the first year.

methodsMELD, BMI, age, diabetes, and the need for dialysis were the five variables used to calculate the LTRS during patients' evaluation for liver transplantation. Mortality rates at 24 h, 30 days, and 1-year were compared among groups of patients with different LTRS. Patients with ABO-incompatibility, redo, multivisceral, partial graft and malignancies except for hepatocellular carcinoma were excluded. Data of 48,616 adult liver transplant recipients were extracted from the Scientific Registry of Transplant Recipients between 2002 and 2017.

results24-h mortality was 0.9%, 1.0%, 1.1%, 1.7%, 2.3%, 2.0% and 3.5% for patients with LTRS of 0,1,2,3,4, 5 and ≥ 6, respectively (P < 0.001). 30-day mortality was 3.5%, 4.2%, 4.9%, 6.2%, 7.6%, 7.2% and 10.1% respectively (P < 0.001). 1-year mortality was 8.6%, 10.8%, 12.9%, 13.9%, 18.5%, 20.3% and 28.6% respectively (P < 0.001). 10-year survival was 61%, 56%, 57%, 54%, 47%, and 31% for patients with 0, 1, 2, 3, 4, 5 and ≥ 6 points respectively (P < 0.001).

conclusionPerioperative mortality and long-term survival of patients undergoing LT can be accurately estimated at the time of listing by the LTRS.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsLiver TransplantationAdultGraft SurvivalHumansRetrospective StudiesRisk FactorsTransplant Recipients

Identifiers

PMID33189566
PMCPMC8110600
OpenAlexW3100599078

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.