Evidence map›Paper›PMID 33189539›Full record

ArticleJournal of vascular and interventional radiology : JVIR2021

Correlation and Agreement of Yttrium-90 Positron Emission Tomography/Computed Tomography with Ex Vivo Radioembolization Microsphere Deposition in the Rabbit VX2 Liver Tumor Model.

Andrew C Gordon, Vanessa L Gates, Sarah B White, Kathleen R Harris, Daniel Procissi, Zhuoli Zhang, Weiguo Li, Donald Samaan, Jodi R Nicolai, Samdeep K Mouli and 6 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07586046 (A Prospective Dose-Escalation Study to Define an Ablative Dose of Yttrium-90 Transarterial Radioembolization Using Advanced Dosimetry and Functional MRI), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07586046 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective Dose-Escalation Study to Define an Ablative Dose of Yttrium-90 Transarterial Radioembolization Using Advanced Dosimetry and Functional MRI (MARGIN Study)

TypeinterventionalSponsorNorthwestern UniversityRan2026 to 2029Enrolled30ConditionsHCC - Hepatocellular CarcinomaArmsYttrium-90 Radiation Segmentectomy (Y90 RS) using glass microspheres
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Andrew C GordonDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois. Electronic address: andrew-gordon@northwestern.edu.
Vanessa L GatesDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Sarah B WhiteDepartment of Radiology, Division of Vascular & Interventional Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Kathleen R HarrisDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Daniel ProcissiDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Zhuoli ZhangDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Weiguo LiDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Donald SamaanMedical Health Physics, Stanford University, Palo Alto, California.
Jodi R NicolaiDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Samdeep K MouliDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Kent T SatoDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Robert K RyuDepartment of Radiology, University of Colorado, Aurora, Colorado.
Reed A OmaryDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Riad SalemDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Medicine, Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Surgery, Organ Transplantation, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Robert J LewandowskiDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Medicine, Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Surgery, Organ Transplantation, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Andrew C LarsonDepartment of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois.
Northwestern University · USMedical College of Wisconsin · USStanford Health Care · USUniversity of Colorado Anschutz Medical Campus · USVanderbilt University Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
MRI-Guided Dendritic-Cell-Based Vaccine Immunotherapy for Pancreatic CancerR01CA209886 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vahid Yaghmai, Zhuoli Zhang · 2016 to 2026
$3.3M
Yittrium-90 radiation lobectomy: Dose optimization and prediction of FLR hypertrophy to enable resection of HCCR01CA233878 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COLLINS, JEREMY DOUGLAS, LEWANDOWSKI, ROBERT J · 2019 to 2025
$3.0M
Cancer Nanotechnology in Imaging and RadiotherapyR25CA132822 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLOSCHAK, GAYLE E. · 2009 to 2013
$2.0M
Image-guided Interventional Combination Liver Cancer ImmunotherapyR01CA241532 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI YAGHMAI, VAHID, ZHANG, ZHUOLI · 2020 to 2024
$1.8M
MRI-Guided Irreversible Electroporation Ablation for Liver TumorsR01CA196967 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ZHANG, ZHUOLI · 2015 to 2018
$1.4M
NCI NIH HHS R01 CA196967NCI NIH HHS R01 CA209886NCI NIH HHS R01 CA233878NCI NIH HHS R01 CA241532NCI NIH HHS R25 CA132822NIGMS NIH HHS T32 GM008152
6 · The paper itself

Abstract

purposeTo demonstrate a stronger correlation and agreement of yttrium-90 ( MATERIALS AND

methodsHepatic VX2 tumors were implanted into New Zealand white rabbits, with growth confirmed by 7 T magnetic resonance imaging. Seventeen VX2 rabbits provided 33 analyzed tumors. Treatment volumes were calculated from manually drawn volumes of interest (VOI) with three-dimensional surface renderings. Radioembolization was performed with glass

resultsThe median infused activity was 33.3 MBq (range, 5.9-152.9). Tumor dose was significantly correlated with

conclusions

Indexed as

Embolization, TherapeuticPositron Emission Tomography Computed TomographyRadiation DosageAnimalsFemaleLiver Neoplasms, ExperimentalNecrosisPredictive Value of TestsRabbitsRadiographic Image Interpretation, Computer-AssistedRadiopharmaceuticalsTumor BurdenYttrium RadioisotopesRadiopharmaceuticalsYttrium Radioisotopes

Identifiers

PMID33189539
PMCPMC8086791
OpenAlexW3102602509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.