ReviewHearing research2021
Translational and interdisciplinary insights into presbyacusis: A multidimensional disease.
Review in Hearing research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults.American journal of human genetics · 2026Article
- Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP).Alzheimer's research & therapy · 2026Article
- Association of Age-Related Hearing Loss with Domain-Specific Cognitive Performance in Older Adults.Journal of clinical medicine · 2026Article
- Distinct cochlear cell types associated with genetic susceptibility to sensory and metabolic hearing loss in older adults from the CLSA.bioRxiv : the preprint server for biology · 2026Article
- Short tandem repeats significantly contribute to the genetic architecture of metabolic and sensory age-related hearing loss phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Cross-Sectional and Longitudinal Analyses of the Association Between Statin Use and Age-Related Hearing Loss.Drugs & aging · 2026Article
- Smoking history and the rate of hearing decline in aging: Results from a longitudinal cohort study.Hearing research · 2026Article
- Insights Into Stria Vascular Function, Stria Immunity, and Age-Related Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025Review
- Sleep Quality in Patients with Tinnitus.Sleep science (Sao Paulo, Brazil) · 2025Article
- The tectorial membrane has a critical role in metabolic age-related hearing loss.EBioMedicine · 2025Article
- Burdens of sense organ diseases across global, regional, and national levels from 1990 to 2021 and projections for 2050.BMC public health · 2025Article
- Generational Differences in Audiometric and Self-Reported Hearing and Hearing Aid Use.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Dissecting the Interactions of Diabetes Mellitus and Hearing Loss with Cognitive Decline and Dementia.Brain sciences · 2025Review
- Improving ototoxicity monitoring in patients receiving aminoglycosides using a novel digital approach: a quality improvement project.BMJ open quality · 2025Article
- Auditory and cognitive contributions to recognition of degraded speech in noise: Individual differences among older adults.PloS one · 2025Article
- Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.Frontiers in aging neuroscience · 2025Review
- Trends and projections of mild and moderate hearing loss among adolescents, young adults, middle-aged adults and age-standardised population in Malaysia from 1996 to 2030.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Pharmacological Approaches to Hearing Loss.Pharmacological reviews · 2024Review
- Prevalence and risk factors of self-reported hearing loss, tinnitus, and dizziness in a population-based sample from rural northeastern Germany.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
There are multiple etiologies and phenotypes of age-related hearing loss or presbyacusis. In this review we summarize findings from animal and human studies of presbyacusis, including those that provide the theoretical framework for distinct metabolic, sensory, and neural presbyacusis phenotypes. A key finding in quiet-aged animals is a decline in the endocochlear potential (EP) that results in elevated pure-tone thresholds across frequencies with greater losses at higher frequencies. In contrast, sensory presbyacusis appears to derive, in part, from acute and cumulative effects on hair cells of a lifetime of environmental exposures (e.g., noise), which often result in pronounced high frequency hearing loss. These patterns of hearing loss in animals are recognizable in the human audiogram and can be classified into metabolic and sensory presbyacusis phenotypes, as well as a mixed metabolic+sensory phenotype. However, the audiogram does not fully characterize age-related changes in auditory function. Along with the effects of peripheral auditory system declines on the auditory nerve, primary degeneration in the spiral ganglion also appears to contribute to central auditory system aging. These inner ear alterations often correlate with structural and functional changes throughout the central nervous system and may explain suprathreshold speech communication difficulties in older adults with hearing loss. Throughout this review we highlight potential methods and research directions, with the goal of advancing our understanding, prevention, diagnosis, and treatment of presbyacusis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.