Evidence map›Paper›PMID 33189110›Full record

ArticleAsian spine journal2021

Effectiveness of Duloxetine for Postsurgical Chronic Neuropathic Disorders after Spine and Spinal Cord Surgery.

Osahiio Tsuji, Shizuko Kosugi, Satoshi Suzuki, Satoshi Nori, Narihito Nagoshi, Eijiro Okada, Nobuyuki Fujita, Mitsuru Yagi, Masaya Nakamura, Morio Matsumoto and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Asian spine journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Osahiio TsujiDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Shizuko KosugiDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Satoshi SuzukiDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Satoshi NoriDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Narihito NagoshiDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Eijiro OkadaDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Nobuyuki FujitaDepartment of Orthopaedic Surgery, Fujita Health University, Aichi, Japan.
Mitsuru YagiDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Masaya NakamuraDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Morio MatsumotoDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Kota WatanabeDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Keio University · JPFujita Health University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designThis is a retrospective observational study with an outpatient setting. PURPOSE: This study aimed to describe the effects of duloxetine (DLX) administration for postsurgical chronic neuropathic disorders (both pain and numbness) following spinal surgery in patients without depression. OVERVIEW OF LITERATURE: Although several reports indicated the potential of DLX to effectively treat postoperative symptoms as a perioperative intervention, there have been no reports of its positive effect on postsurgical chronic neuropathic disorders.

methodsA total of 24 patients with postsurgical chronic pain and/or numbness Numeric Rating Scale (NRS) scores of ≥4 were enrolled. All patients underwent spine or spinal cord surgery at Keio University Hospital and received daily administration of DLX for more than 3 months. The mean postoperative period before the first administration of DLX was 35.5±57.0 months. DLX was administered for more than 3 months at a dose of 20, 40, or 60 mg/day, and the degree of pain and numbness was evaluated using the NRS before administration and 3 months after administration. Effectiveness was defined as more than a 2-point decrease in the NRS score following administration.

resultsIn terms of the type of symptoms, 15 patients experienced only numbness, eight experienced both pain and numbness, and one experienced only pain. Of the 24 patients, 19 achieved effective relief with DLX. DLX was effective for all patients with postsurgical chronic pain (n=9), and it reduced postsurgical chronic numbness in 18 of 23 patients. No significant difference was observed in background spinal disorders. DLX was not effective for five patients who complained only of postsurgical chronic numbness.

conclusionsThis study reports the effectiveness of DLX for postsurgical chronic neuropathic disorders. Although DLX reduced postsurgical chronic pain (efficacy rate=100%) and numbness (78.3%) in certain patients, further investigation is needed to determine its optimal use.

Indexed as

Chronic painDuloxetine hydrochlorideNumbnessPostsurgical neuropathic disorders

Identifiers

PMID33189110
PMCPMC8561146
OpenAlexW3102026882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.