Evidence map›Paper›PMID 33188991›Full record

ArticleBreast (Edinburgh, Scotland)2020

Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses.

Juanjuan Gu, Eric C Polley, Redouane Ternifi, Rohit Nayak, Judy C Boughey, Robert T Fazzio, Mostafa Fatemi, Azra Alizad

Abstract readEvaluation Study
In one paragraph

Article in Breast (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Correlation between SWE parameters and histopathological features and immunohistochemical biomarkers in invasive breast cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juanjuan GuDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Eric C PolleyBiomedical Statistics and Informatics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Redouane TernifiDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Rohit NayakDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Judy C BougheyDepartment of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Robert T FazzioDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Mostafa FatemiDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
Azra AlizadDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA; Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA. Electronic address: aza@mayo.edu.

Funding

Combined Acoustic Imaging and Viscoelastic Parameters Estimation in Breast CancerR01CA148994 · NCI · MAYO CLINIC ROCHESTER · PI ALIZAD, AZRA · 2011 to 2015
$2.4M
NCI NIH HHS R01 CA148994
6 · The paper itself

Abstract

purposeTo investigate the diagnostic role of new metrics, defined as individualized-thresholding of Shear Wave Elastography (SWE) parameters, in association with clinical factors (such as age, mammographic density, lesion size and depth) and the BI-RADS features in differentiating benign from malignant breast lesions.

methodsOf 644 consecutive patients (median age, 55 years), prospectively referred for evaluation, 659 ultrasound detected breast lesions underwent SWE measurements. Multivariable logistic regression analysis was used to estimate the probability of malignancy. The area under the curve (AUC), optimal cutoff value, and the corresponding sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined.

results265 of 659 (40.2%) masses were malignant. Using two E

conclusionsThe false-positive rate can be significantly reduced when applying two E

Indexed as

AdolescentAdultAgedAged, 80 and overArea Under CurveBreastBreast NeoplasmsDiagnosis, DifferentialElasticity Imaging TechniquesFemaleHumansLogistic ModelsMiddle AgedPrecision MedicinePredictive Value of TestsProspective StudiesBreast cancerBreast massesElastographyShear wave elastographyUltrasound

Identifiers

PMID33188991
PMCPMC7670190

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.