Evidence map›Paper›PMID 33188660›Full record

ArticleAging2020

Downregulation of interleukin-6 and C-reactive protein underlies a novel inhibitory role of microRNA-136-5p in acute lower extremity deep vein thrombosis.

Minghui Ou, Shaobo Hao, Jing Chen, Shibo Zhao, Shichao Cui, Jie Tu

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Cytokines and microRNAs in SARS-CoV-2: What do we know?Molecular therapy. Nucleic acids · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Minghui OuDepartment of Vascular Surgery, Qingdao Municipal Hospital, Qingdao 266011, P.R. China.
Shaobo HaoDepartment of Emergency, Qingdao Municipal Hospital, Qingdao 266011, P.R. China.
Jing ChenDepartment of Vascular Surgery, Qingdao Municipal Hospital, Qingdao 266011, P.R. China.
Shibo ZhaoDepartment of Vascular Surgery, Qingdao Municipal Hospital, Qingdao 266011, P.R. China.
Shichao CuiDepartment of Vascular Surgery, Qingdao Municipal Hospital, Qingdao 266011, P.R. China.
Jie TuDepartment of Science and Education, Qingdao Municipal Hospital, Qingdao 266011, P.R. China.
Qingdao University · CNQingdao Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep vein thrombosis (DVT) comprises a critical and common health condition with high incidence, mortality, and long-term adverse sequelae. Several differentially expressed microRNAs (miRNAs) have emerged as promising prognostic markers in DVT. The present study intended to explore the functional relevance of miR-136-5p in acute lower extremity DVT (LEDVT). Rat models of acute LEDVT were established and miR-136-5p expression was altered by agomir or antagomir to assess its effects. In addition,

Indexed as

AdultAgedAged, 80 and overAnimalsC-Reactive ProteinDown-RegulationFemaleHumansInterleukin-6MaleMicroRNAsMiddle AgedRats, Sprague-DawleyVenous ThrombosisC-Reactive ProteinIL6 protein, humanInterleukin-6MicroRNAsMIRN136 microRNA, humanacute lower extremity deep vein thrombosisinterleukin-6microRNA-136-5p

Identifiers

PMID33188660
PMCPMC7695373
OpenAlexW3083892309

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.