Evidence map›Paper›PMID 33188492›Full record

ArticleEcotoxicology (London, England)2021

DNA damage of human derived liver cell line HL-7702 induced by organic extracts from surface water in Pearl River Delta, China.

Zhendong Wu, Dedong Wang, Jiguo Wu, Ying Guan, Yunxia Jiang, Yi Zhong, Guoxia Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Ecotoxicology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhendong Wu *Department of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Dedong Wang *Guangzhou Center for Disease Control and Prevention, 510440, Guangzhou, China.
Jiguo WuDepartment of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Ying GuanDepartment of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Yunxia JiangDepartment of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Yi ZhongGuangzhou Center for Disease Control and Prevention, 510440, Guangzhou, China.
Guoxia ZhangDepartment of Environmental Health, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, 510515, Guangzhou, China. guoxiazhang@126.com.ORCID http://orcid.org/0000-0003-2530-3238

Funding

Science and Technology Program of Guangzhou 201904010161
6 · The paper itself

Abstract

Many organic pollutants attract public health concern due to their genotoxicity. To investigate the genotoxicity of organic matter in surface water of the Pearl River Delta (PRD). Organic substances of 24 samples (dry and wet season) from North River, West River and East River were extracted from 60 L source water by XAD-2 macroporous resin. DNA damage effect of organic extracts was tested in human derived liver cells (HL-7702), using single cell gel electrophoresis (SCGE) assay. The results showed that 100% organic extracts (24/24) could induce DNA damage in HL-7702 cells when the concentration was above 1.0 L surface water/ml culture, no significant difference of DNA damage between dry and wet seasons was observed. The organic substance-induced DNA damage in HL-7702 cells was significantly (P < 0.05) correlated with the contents of Dissolved Organic Carbon in both seasons and Total Suspended Solids in dry season. In conclusion, organic extracts induced genetic damage in HL-7702 cells, indicating potential genotoxicity of organic pollutants of surface water from PRD, South China.

Indexed as

DNA DamageRiversWater Pollutants, ChemicalCell LineChinaEnvironmental MonitoringHumansLiverSeasonsWaterWaterWater Pollutants, ChemicalComet assayDNA damage;HL-7702 cells;Organic extracts;Surface water;

Identifiers

PMID33188492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.