Evidence map›Paper›PMID 33188477›Full record

ArticleJournal of neurology2021

Myelin oligodendrocyte glycoprotein-antibody-associated disorder: a new inflammatory CNS demyelinating disorder.

Manjunath Netravathi, Vikram Venkappayya Holla, Atchayaram Nalini, Ravi Yadav, Seena Vengalil, Abel Thomas Oommen, Sultana Shaik Reshma, Nitish Kamble, Priya Treesa Thomas, Bhat Maya and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Attack phenotypes and disease course in pediatric MOGAD.Annals of clinical and translational neurology · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Manjunath NetravathiDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India. sundernetra@yahoo.co.in.ORCID http://orcid.org/0000-0002-8899-8578
Vikram Venkappayya HollaDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Atchayaram NaliniDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Ravi YadavDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Seena VengalilDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Abel Thomas OommenDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Sultana Shaik ReshmaDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Nitish KambleDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Priya Treesa ThomasDepartment of Psychiatry Social Work, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
Bhat MayaDepartment of Neuroimaging & Interventional Neuroradiology (NIIR), National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India.
Pramod Kumar PalDepartment of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, 560029, India.
Anita MahadevanDepartment of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
National Institute of Mental Health and Neurosciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsMyelin oligodendrocyte glycoprotein (MOG) is an oligodendrocytopathy resulting in demyelination. We aimed to determine the frequency of MOG-associated disorders (MOGAD), its various clinical phenotypes, and imaging characteristics.

methodsAll patients with MOGAD were included. Description of the various clinical phenotypes, investigation profile, therapeutic response, differences between pediatric and adult-onset neurological disorders, determination of poor prognostic factors was done.

resultsThe study population consisted of 93 (M:F = 45:48) (Pediatric:40, Adult-onset:47, Late-onset:7) patients with a median age of 21 years. Among the 263 demyelinating episodes; 45.8% were optic neuritis (ON), 22.8% were myelopathy, 17.1% were brainstem, 7.6% were acute demyelinating encephalomyelitis(ADEM), 4.2% were opticomyelopathy and 2.3% with cerebral manifestations. There was exclusive vomiting in 24.7% prior to onset of clinical syndrome, none of them had area postrema involvement. ADEM was exclusively seen in pediatric patients. Poor prognostic indicators included: (i) incomplete recovery from an acute attack, (b) brainstem syndrome, (c) ADEM with incomplete recovery, (d) MRI suggestive of leukodystrophy pattern, (e) severe ON, (f) ADEMON.

conclusionsThe Spectrum of MOG-associated disorders is wider affecting the brain (grey and white matter) and the meninges. There are various clinical phenotypes and MRI patterns, recognition of which may help in the determination of therapeutic strategies, and long-term prognosis.

Indexed as

Demyelinating DiseasesEncephalomyelitisNeuromyelitis OpticaOptic NeuritisAdultAutoantibodiesChildHumansMyelin-Oligodendrocyte GlycoproteinYoung AdultAutoantibodiesMyelin-Oligodendrocyte GlycoproteinAcute demyelinating encephalomyelitisADEMLETMLeukodystrophyLongitudinally extensive myelitisMOGMOGADMyelin oligodendrocyte proteinNeuromyelitis optica spectrum disordersNMOSD

Identifiers

PMID33188477
OpenAlexW3103301315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.