ArticleEuropean journal of clinical pharmacology2021
Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department.
Article in European journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Increasing the reporting of adverse drug reaction-related hospitalizations using an ICD-10-based identification workflow: A multicentre study from Switzerland.British journal of clinical pharmacology · 2026Observational
- Characteristics, preventability, management, and predictors of adverse drug reaction-related hospital admissions: a cross-sectional study in a Thai tertiary care hospital.Journal of pharmaceutical policy and practice · 2026Article
- Drug-related emergency department visits in Qatar: a prospective cohort study.BMC emergency medicine · 2025Observational
- Trends in adverse drug reaction reporting in eight selected countries after the implementation of new pharmacovigilance regulation in 2012: a joinpoint regression analysis.European journal of clinical pharmacology · 2025Article
- Comparative Analysis of Drugs Frequently Suspected of Causing Adverse Drug Reactions Reported via the Spontaneous Reporting System Versus in a Prospective Multicentre Cohort Study in Hospital Emergency Departments.Journal of clinical medicine · 2025Article
- Role of red blood cells in clinically relevant bleeding tendencies and complications.Journal of thrombosis and haemostasis : JTH · 2023Review
- Hospitalisations Related to Adverse Drug Reactions in Switzerland in 2012-2019: Characteristics, In-Hospital Mortality, and Spontaneous Reporting Rate.Drug safety · 2023Article
- Effect of Information Intervention on Prescribing Practice for Neuropathic Pain in Older Patients: A Nationwide Register-Based Study.Drugs & aging · 2023Article
- Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT).British journal of clinical pharmacology · 2023Observational
- [Practical limitations of medical clarification and informed consent in the context of drug therapy].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2022Article
- Healthcare costs and mortality associated with serious fluoroquinolone-related adverse reactions.Pharmacology research & perspectives · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the characteristics of ADRs in patients admitting at the emergency room of a tertiary hospital.
methodsWe collected the patient records of 1600 emergency room visits of a university hospital in 2018. The patient files were studied retrospectively and all possible ADRs were identified and registered. Patient characteristics, drugs associated with ADRs, causality, severity, preventability, and the role of pharmacogenetics were assessed.
resultsThere were 125 cases with ADRs, resulting in a 7.8% overall incidence among emergency visits. The incidence was greatest in visits among elderly patients, reaching 14% (men) to 19% (women) in the 80-89 years age group. The most common causative drugs were warfarin, acetylsalicylic acid (ASA), apixaban, and docetaxel, and the most common ADRs were bleedings and neutropenia and/or severe infections. Only two of the cases might have been prevented by pharmacogenetic testing, as advised in Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines.
conclusionThe same ATC classes, antithrombotics and cytostatics, were involved in ADRs causing university clinic hospitalizations as those identified previously in drug-related hospital fatalities. It seems difficult to prevent these events totally, as the treatments are vitally important and their risk-benefit-relationships have been considered thoroughly, and as pharmacogenetic testing could have been useful in only few cases.
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