Evidence map›Paper›PMID 33188441›Full record

ReviewCurrent gastroenterology reports2020

Emerging Therapies to Prevent Post-ERCP Pancreatitis.

Nikhil R Thiruvengadam, Michael L Kochman

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current gastroenterology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06250803 (Early Versus Late Pancreatic Stent Placement for Preventing Post-ERCP Pancreatitis), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06250803 narecruitingnot on this mapstarted 2024, after this paper: background citation

Early Versus Late Pancreatic Stent Placement for Preventing Post-ERCP Pancreatitis: a Multicentre, Randomised Trial

TypeinterventionalSponsorThe First Affiliated Hospital of Anhui Medical UniversityRan2024 to 2026Enrolled768ConditionsCholangiopancreatography, Endoscopic Rretrograde, Post-ERCP PancreatitisArmsearly pancreatic stent placement (EPSP)
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Why is the rectal route for NSAIDS favorable for preventing post-ERCP pancreatitis?Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2025
    Article
  6. Review
  7. Review
  8. Endoscopic Retrograde Cholangiopancreatography in Pediatric Population: A Decade-Long Experience from 2 Tertiary Centers.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nikhil R ThiruvengadamDivision of Gastroenterology and Hepatology, University of California San Francisco, 513 Parnassus Avenue, S-357, Box 0538, San Francisco, CA, 94143-0538, USA. Nikhil.Thiruvengadam@ucsf.edu.
Michael L KochmanGastroenterology Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
University of California, San Francisco · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe aim of this review is to evaluate emerging, novel therapies for the prevention of post-ERCP pancreatitis. RECENT

findingsRectal indomethacin reduces the risk of pancreatitis in low- and average-risk patients, who comprise the majority of patients undergoing ERCP. An 8-h protocol of aggressive lactated Ringer's reduces the risk of pancreatitis in average-risk patients. Sublingual nitrate may provide additional benefit to rectal NSAIDs in preventing PEP. A tacrolimus trough > 2.5 ng/mL was recently shown to be associated with a lower risk of PEP in liver transplant patients undergoing ERCP. Routine usage of rectal indomethacin in all patients undergoing ERCP reduces the risk of PEP. Pancreatic-duct stents reduce the risk of PEP in high-risk patients. There is emerging data that aggressive hydration with lactated Ringer's and nitrates may further reduce PEP. Tacrolimus is a promising potential agent to prevent PEP but needs further clinical study.

Indexed as

Administration, RectalAnti-Inflammatory Agents, Non-SteroidalCholangiopancreatography, Endoscopic RetrogradeHumansImmunosuppressive AgentsIndomethacinNitro CompoundsPancreatic DuctsPancreatitisRinger's LactateStentsTacrolimusAnti-Inflammatory Agents, Non-SteroidalImmunosuppressive AgentsIndomethacinNitro CompoundsRinger's LactateTacrolimusLactated ringer’sPancreatic duct stentsPost-ERCP pancreatitisRectal indomethacinTacrolimus

Identifiers

PMID33188441
OpenAlexW3104687692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.