ArticleCerebral cortex (New York, N.Y. : 1991)2021
Atlas55+: Brain Functional Atlas of Resting-State Networks for Late Adulthood.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Impact of Computerized Cognitive Training on Default Mode Network Connectivity in Subjects at Risk for Alzheimer's Disease: A 78-week Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2023Trial
- Plasma vitamin C levels are associated with brain structural networks on MRI: A large cohort study.PloS one · 2026Article
- Lifespan dynamics of STN-based functional connectivity and network properties: Implications for motor dysfunction and circuit-based neuromodulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- A Functional Resting-State Network Atlas Based on 420 Older Adults with Hypertension.bioRxiv : the preprint server for biology · 2025Article
- Altered connectivity among the triple brain networks in patients with mild cognitive impairment: a source-based morphometry study with a large elderly population.Japanese journal of radiology · 2025Article
- Dev-Atlas: A reference atlas of functional brain networks for typically developing adolescents.Developmental cognitive neuroscience · 2025Article
- Age- and Sex-Specific Patterns in Adult Brain Network Segregation.Human brain mapping · 2025Article
- When age tips the balance: A dual mechanism affecting hemispheric specialization for language.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neural correlates underlying local and global processing during visual search across adulthood.PloS one · 2024Article
- Influence of atlas-choice on age and time effects in large-scale brain networks in the context of healthy aging.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- When Age Tips the Balance: a Dual Mechanism Affecting Hemispheric Specialization for Language.bioRxiv : the preprint server for biology · 2023Article
- Resting state network connectivity alterations in HIV: Parallels with aging.Human brain mapping · 2023Article
- Striatonigrostriatal connectivity-based cross-species parcellation of human and macaque substantia nigra.Human brain mapping · 2023Article
- Mapping cross-species connectome atlas of human and macaque striatum.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Changes of creative ability and underlying brain network connectivity throughout the lifespan.Brain and cognition · 2023Article
- Disruption of locus coeruleus-related functional networks in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Age-dependent changes in the dynamic functional organization of the brain at rest: a cross-cultural replication approach.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing.Human brain mapping · 2023Article
- A framework For brain atlases: Lessons from seizure dynamics.NeuroImage · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Currently, several human brain functional atlases are used to define the spatial constituents of the resting-state networks (RSNs). However, the only brain atlases available are derived from samples of young adults. As brain networks are continuously reconfigured throughout life, the lack of brain atlases derived from older populations may influence RSN results in late adulthood. To address this gap, the aim of the study was to construct a reliable brain atlas derived only from older participants. We leveraged resting-state functional magnetic resonance imaging data from three cohorts of healthy older adults (total N = 563; age = 55-95 years) and a younger-adult cohort (N = 128; age = 18-35 years). We identified the major RSNs and their subdivisions across all older-adult cohorts. We demonstrated high spatial reproducibility of these RSNs with an average spatial overlap of 67%. Importantly, the RSNs derived from the older-adult cohorts were spatially different from those derived from the younger-adult cohort (P = 2.3 × 10-3). Lastly, we constructed a novel brain atlas, called Atlas55+, which includes the consensus of the major RSNs and their subdivisions across the older-adult cohorts. Thus, Atlas55+ provides a reliable age-appropriate template for RSNs in late adulthood and is publicly available. Our results confirm the need for age-appropriate functional atlases for studies investigating aging-related brain mechanisms.
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