ArticleCerebral cortex (New York, N.Y. : 1991)2021
Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging.GeroScience · 2026Article
- tDCS improves early Alzheimer's disease by synaptic vesicle fusion and release.Military Medical Research · 2026Article
- Article
- A feasibility study of the effects of concurrent transcranial direct current stimulation (tDCS) on mindfulness training in adults living with overweight or obesity: the MINDED trial protocol.Pilot and feasibility studies · 2026Article
- Exercise modulates behavioral and neural mechanisms of working memory in excessive short video users.Frontiers in psychology · 2026Article
- In vivo mapping of infant brain microstructure with neurite orientation dispersion and density imaging.Brain structure & function · 2025Review
- Curiosity and surprise differentially affect memory depending on age.Scientific reports · 2025Article
- An fNIRS-based investigation of cerebral hemodynamic responses during verbal fluency task and n-back task in individuals with mild cognitive impairment.Frontiers in neurology · 2025Article
- Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words.GeroScience · 2024Article
- Differences in Brain Volume in Military Service Members and Veterans After Blast-Related Mild TBI: A LIMBIC-CENC Study.JAMA network open · 2024Article
- Integrating Neuroimaging and Genetics via Contrastive Learning for Working Memory.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024Article
- Brain imaging of a gamified cognitive flexibility task in young and older adults.Brain imaging and behavior · 2024Article
- Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer's dementia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- The impact of a tDCS and cognitive training intervention on task-based functional connectivity.GeroScience · 2024Article
- Increased Resting-State Functional Connectivity in Patients With Autoimmune Addison Disease.The Journal of clinical endocrinology and metabolism · 2024Article
- Changes in Multiparametric Magnetic Resonance Imaging and Plasma Amyloid-Beta Protein in Subjective Cognitive Decline.Brain sciences · 2023Article
- Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy.Neuroimage. Reports · 2023Article
- DNA methylation of the oxytocin receptor interacts with age to impact neural response to social stimuli.Frontiers in aging neuroscience · 2023Article
- The association between head motion during functional magnetic resonance imaging and executive functioning in older adults.Neuroimage. Reports · 2022Article
- Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults.GeroScience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
Abstract
Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.