Evidence map›Paper›PMID 33188287›Full record

ArticleCommunications biology2020

Targeting endothelin 1 receptor-miR-200b/c-ZEB1 circuitry blunts metastatic progression in ovarian cancer.

Rosanna Sestito, Roberta Cianfrocca, Piera Tocci, Laura Rosanò, Andrea Sacconi, Giovanni Blandino, Anna Bagnato

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Non-Coding RNAs in Breast Cancer: Diagnostic and Therapeutic Implications.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. The new world of RNA diagnostics and therapeutics.Journal of experimental & clinical cancer research : CR · 2023
    Article
  8. Article
  9. Article
  10. ZNF384-ZEB1 feedback loop regulates breast cancer metastasis.Molecular medicine (Cambridge, Mass.) · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rosanna SestitoPreclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.ORCID 0000-0001-5460-2777
Roberta CianfroccaPreclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.
Piera TocciPreclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.ORCID 0000-0003-3771-013X
Laura RosanòPreclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.
Andrea SacconiOncogenomic and Epigenetic Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.
Giovanni BlandinoOncogenomic and Epigenetic Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy.ORCID 0000-0002-6970-2241
Anna BagnatoPreclinical Models and New Therapeutic Agents Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy. annateresa.bagnato@ifo.gov.it.ORCID 0000-0002-7269-9522
Istituti di Ricovero e Cura a Carattere Scientifico · ITInstitute of Molecular Biology and Pathology · ITNational Cancer Institute · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of regulatory mechanisms underlying the poor prognosis of ovarian cancer is necessary for diagnostic and therapeutic implications. Here we show that endothelin A receptor (ET

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorDrug Delivery SystemsEndothelin A Receptor AntagonistsFemaleGene Expression Regulation, NeoplasticHumansMiceMice, NudeMicroRNAsNeoplasm MetastasisNeoplasms, ExperimentalOvarian NeoplasmsPyrimidinesReceptor, Endothelin AAntineoplastic AgentsEndothelin A Receptor AntagonistsmacitentanMicroRNAsMIRN200 microRNA, humanPyrimidinesReceptor, Endothelin ASulfonamidesZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1

Identifiers

PMID33188287
PMCPMC7666224
OpenAlexW3098745174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.