ArticleNature communications2020
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Plant-Derived Substances for Prevention of Necrotising Enterocolitis: A Systematic Review of Animal Studies.Nutrients · 2024Pooled it
- Research focus and emerging trends of the gut microbiome and infant: a bibliometric analysis from 2004 to 2024.Frontiers in microbiology · 2024Pooled it
- Maternal and infant gut microbiome.iMeta · 2026Review
- Cytokine multimerization: when more is more and sometimes less.Nature reviews. Immunology · 2026Review
- Role of itaconate in intestinal disease (Review).International journal of molecular medicine · 2026Review
- Blockade of NKp46⁻ CCR6⁻ ILC3 autophagy protects against necrotizing enterocolitis by restoring energy metabolism balance in mice.Nature communications · 2026Article
- Elucidating shared genes and pathways in programmed cell death with necrotizing enterocolitis: insights into novel therapeutic targets and glutathione.Translational pediatrics · 2026Article
- CD177⁺ neutrophil-platelet aggregates contribute to thromboinflammation via NETs in necrotizing enterocolitis.Nature communications · 2026Article
- Surgical Necrotising Enterocolitis (S-NEC): Where We Stand Today: A Narrative Review.Journal of clinical medicine · 2026Review
- [Clinical significance of neutrophil chemokines in intestinal tissue and related receptor expression in peripheral blood in neonatal necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Characteristics of T-Cells Expressing IL-37 and Its Receptors in Inflammatory Bowel Disease.International journal of molecular sciences · 2026Article
- Dysregulated immunometabolism in gut inflammation.Acta biochimica et biophysica Sinica · 2026Review
- Local Peritoneal Cytokine Response IL-1β, IL-6, TNF-α in a Standardized Neonatal Rat Model of Necrotizing Enterocolitis.International journal of molecular sciences · 2026Article
- Integrated multi-omics analysis reveals dendritic cell centered regulatory networks and therapeutic targets in necrotizing enterocolitis.Frontiers in immunology · 2026Article
- The role of myeloid cells in the pathogenesis of necrotizing enterocolitis; a scoping review.Frontiers in pediatrics · 2026Review
- Serum LRG1 as a diagnostic marker of necrotizing enterocolitis in preterm infants.Frontiers in pediatrics · 2026Article
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- Ferrostatin-1 protects against necrotizing enterocolitis intestinal injury by inhibiting ferroptosis.Pediatric surgery international · 2025Article
- The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis.Seminars in immunopathology · 2025Review
- The Nonbacterial Infant Microbiome and Necrotizing Enterocolitis.American journal of perinatology · 2025Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 13 institutions in 4 countries.
Steven X ChoDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Ina RudloffDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-7885-110X
Jason C LaoDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Merrin A PangDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Rimma GoldbergDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Christine B BuiDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Catriona A McLeanDepartment of Anatomical Pathology, Alfred Hospital, Melbourne, VIC, Australia.
Magdalena StockZIK Septomics, Jena University Hospital, Jena, Germany.
Tilman E KlassertZIK Septomics, Jena University Hospital, Jena, Germany.
Hortense SlevogtZIK Septomics, Jena University Hospital, Jena, Germany.
Niamh E ManganDepartment of Molecular and Translational Science, Monash University, Melbourne, VIC, Australia.
Wei ChengDepartment of Surgery, Beijing United Family Hospital, Beijing, China.
Doris FischerDepartment of Pediatrics, Goethe University Hospital, Frankfurt, Germany.
Stefan GfroererDepartment of Pediatric Surgery, Goethe University Hospital, Frankfurt, Germany.
Manjeet K SandhuDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Devi NgoDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Alexander BujotzekRoche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany.ORCID 0000-0001-5052-0221
Laurent LariviereRoche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany.
Felix SchumacherRoche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany.
Georg TiefenthalerRoche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany.
Friederike BekerMater Research Institute, University of Queensland, Brisbane, QLD, Australia.
Clare CollinsNeonatal Services, Mercy Hospital for Women, Melbourne, VIC, Australia.
C Omar F KamlinDepartment of Newborn Research, Royal Women's Hospital, Melbourne, VIC, Australia.
Kai KönigMedicum Wesemlin, Department of Paediatrics, Lucerne, Switzerland.
Atul MalhotraDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.ORCID 0000-0001-9664-4182
Kenneth TanDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-1931-0549
Christiane ThedaDepartment of Newborn Research, Royal Women's Hospital, Melbourne, VIC, Australia.ORCID 0000-0001-7577-6004
Alex VeldmanRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Andrew M EllisdonBiomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.
James C WhisstockBiomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.
Philip J BergerDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Claudia A Nold-PetryDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia.
Marcel F NoldDepartment of Paediatrics, Monash University, Melbourne, VIC, Australia. marcel.nold@monash.edu.ORCID 0000-0001-9682-4618
Hudson Institute of Medical Research · AURoche Pharma AG (Germany) · DEJena University Hospital · DEGoethe University Frankfurt · DERoyal Women's Hospital · AUAustralian Regenerative Medicine Institute · AUAustralian Research Council · AUBeijing United Family Hospital · CNHokkaido University · JPJustus-Liebig-Universität Gießen · DEMercy Hospital for Women · AUThe Alfred Hospital · AUThe University of Queensland · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Necrotizing enterocolitis (NEC) is a severe, currently untreatable intestinal disease that predominantly affects preterm infants and is driven by poorly characterized inflammatory pathways. Here, human and murine NEC intestines exhibit an unexpected predominance of type 3/T
Indexed as
Adaptive ImmunityAnimalsAnimals, NewbornBiomarkersEnterocolitis, NecrotizingHomeostasisHumansImmunity, InnateInfant, NewbornInflammation MediatorsInterleukin-1Intestinal MucosaLymphocytesMice, Inbred C57BLMice, TransgenicToll-Like ReceptorsBiomarkersIL37 protein, humanInflammation MediatorsInterleukin-1Toll-Like Receptors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.