Evidence map›Paper›PMID 33188160›Full record

ArticleAging2020

Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma.

Lijuan Cui, Huan Xue, Zhitong Wen, Zhihong Lu, Yunfeng Liu, Yi Zhang

Abstract readValidation Study
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lijuan CuiDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Huan XueDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Zhitong WenDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Zhihong LuDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Yunfeng LiuDepartment of Endocrinology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China.
Yi ZhangDepartment of Pharmacology, School of Basic Medicine, Shanxi Medical University, Taiyuan 030001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. The aim of this study was to identify key metabolic genes related to hepatocellular carcinoma, and to explore their clinical significance. We downloaded mRNA expression profiles and clinical hepatocellular carcinoma data from The Cancer Genome Atlas database to explore the prognostic roles of metabolic genes. Five prognosis-associated metabolic genes, including

Indexed as

Cellular ReprogrammingGene Expression ProfilingNomogramsTranscriptomeAgedBiomarkers, TumorCarcinoma, HepatocellularDatabases, GeneticEnergy MetabolismFemaleGene Regulatory NetworksHumansLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsBiomarkers, Tumorhepatocellular carcinomametabolic reprogrammingprognosticsurvival analysisTCGA

Identifiers

PMID33188160
PMCPMC7695384

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.