Evidence map›Paper›PMID 33188153›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

PARP1: A Potential Molecular Marker to Identify Cancer During Colposcopy Procedures.

Paula Demétrio de Souza França, Navjot Guru, Abigail R Kostolansky, Audrey Mauguen, Giacomo Pirovano, Susanne Kossatz, Sheryl Roberts, Marcio Abrahão, Snehal G Patel, Kay J Park and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Optical and Optoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Paula Demétrio de Souza FrançaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Navjot GuruDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Abigail R KostolanskyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Audrey MauguenDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Giacomo PirovanoDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Susanne KossatzDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Sheryl RobertsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Marcio AbrahãoDepartment of Otorhinolaryngology and Head and Neck Surgery, Federal University of São Paulo, São Paulo, Brazil.
Snehal G PatelDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Kay J ParkDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; jewelle@mskcc.org.
Elizabeth JewellDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USCornell University · USPrinceton University · USUniversidade Federal de São Paulo · BR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
Non-destructive and instant intraoperative margin assessment of high grade dysplasia and cancer of the cervix and vulvaR43CA235995 · NCI · SUMMIT BIOMEDICAL IMAGING, LLC · PI BRAND, CHRISTIAN, REINER, THOMAS · 2019 to 2019
$300k
NCI NIH HHS P30 CA008748NCI NIH HHS R43 CA235995
6 · The paper itself

Abstract

Despite efforts in prevention, cervical cancer still presents with a high worldwide incidence and remains a great problem in public health, especially in low-income countries. Screening programs, such as colposcopy with Papanicolaou testing, have greatly improved mortality rates. However, the agents currently used to delineate those lesions (topical application of acetic acid or Lugol iodine) lack specificity and sometimes can lead to unnecessary biopsies or even cervical excisions. A tool to enable in vivo histology to quickly and quantitatively distinguish between tumor, dysplastic tissue, and healthy tissue would be of great clinical interest.

Indexed as

Biomarkers, TumorColposcopyPoly (ADP-Ribose) Polymerase-1Uterine Cervical NeoplasmsFemaleHumansBiomarkers, TumorPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1cervical cancerfluorescence-guided surgeryPARP1PARPi-FL

Identifiers

PMID33188153
PMCPMC8882878
OpenAlexW3100990162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.