ArticleScience immunology2020
Cellular context of IL-33 expression dictates impact on anti-helminth immunity.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 131 citations in OpenAlex.
- Trial
- IL-33 as a boundary-tissue state-transfer signal: a Reader-Alarmin-Effector architecture linking CNS and skin.Brain, behavior, & immunity - health · 2026Review
- The Role of the IL-33/ST2 Axis in Nervous System Development and Diseases.Immunology and cell biology · 2026Review
- Targeting ANGPTL3 and IL-33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanisms of the IL-33/ST2 Signaling Axis in Regulating Bone Metabolism.Biomolecules · 2026Review
- Co-infection with a viral pathogen (Theiler's murine encephalomyelitis virus) tended to improve host tolerance but significantly enhanced resistance to Heligmosomoides bakeri.Veterinary research communications · 2026Article
- Perforin-2 enhances antigen-specific CTL immune response by promoting cross presentation.Cell death & disease · 2026Article
- The Application of Single-cell RNA Sequencing Technology in the Research of Sino-Nasal Diseases.Clinical reviews in allergy & immunology · 2026Review
- Distinguishing Features of ILC2s During Type 2 Immune Responses.European journal of immunology · 2026Review
- Fibroblast-derived alarmin promotes oral wound healing by activating regulatory T cells that relay pro-angiogenic and anti-inflammatory responses.Cell reports · 2026Article
- Early life group 2 innate lymphoid cells in health and disease.Molecular and cellular pediatrics · 2026Review
- The exploration of immunological landscape and drug targets in chronic rhinosinusitis with nasal polyps.The World Allergy Organization journal · 2026Article
- Nicheformer: a foundation model for single-cell and spatial omics.Nature methods · 2025Article
- Crosstalk between the microbiota and intestinal dendritic cells in IBD.Seminars in immunopathology · 2025Review
- New Perspectives on Classical Alarmin Responses to Intestinal Helminth Infection.Parasite immunology · 2025Review
- Organoids in parasitology: a game-changer for studying host-nematode interactions.Parasitology · 2025Review
- SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps.Experimental & molecular medicine · 2025Article
- Myeloid-derived IL-33 drives γδ T cell-dependent resistance against cutaneous infection by Strongyloides ratti.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Article
- Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis.Mucosal immunology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Li-Yin HungDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7623-1946
Yukinori TanakaDepartment of Dental Anesthesiology and Pain Management, Tohoku University Hospital, Sendai, Miyagi 980-8574, Japan.ORCID 0000-0001-6170-2960
Karl HerbineDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1973-7817
Christopher PastoreDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1002-6138
Brenal SinghDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-1275-0434
Annabel FergusonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nisha VoraDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bonnie DouglasDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1039-7158
Kelly ZulloDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Edward M BehrensDivision of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Tiffany Li Hui TanDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-6321-9710
Michael A KohanskiDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8399-364X
Paul BryceImmunology and Inflammation Therapeutic Area, Sanofi US, Cambridge, MA 02319, USA.ORCID 0000-0001-6455-3155
Cailu LinMonell Chemical Senses Center, Philadelphia, PA 19104, USA.ORCID 0000-0001-8909-7758
Taku KambayashiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Danielle R ReedMonell Chemical Senses Center, Philadelphia, PA 19104, USA.ORCID 0000-0002-4374-6107
Breann L BrownDepartment of Biochemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-8109-4472
Noam A CohenDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA 19104, USA.
De'Broski R HerbertDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. debroski@vet.upenn.edu.ORCID 0000-0002-2449-5365
University of Pennsylvania · USMonell Chemical Senses Center · USChildren's Hospital of Philadelphia · USInflammation Research Foundation · USTohoku University Hospital · JPVanderbilt University · US
Funding
Trefoil factor proteins regulate inflammation and immunityU01AI125940 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2016 to 2021
$2.8MAlternative Macrophage Activation Limits ImmunopathologyR01GM083204 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2007 to 2018
$2.5MTrefoil Factors Regulate Th2 ImmunityR01AI095289 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2011 to 2015
$2.1MPhysiological roles of schistosome TRP ion channels with atypical pharmacologyR01AI123173 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 2017 to 2021
$2.0MUsing transgenic parasitic nematodes to investigate Type 2 immunityR21AI144572 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R, LOK, JAMES B · 2019 to 2020
$443kNIAID NIH HHS R01 AI095289NIAID NIH HHS R01 AI123173NIAID NIH HHS R21 AI144572NIAID NIH HHS U01 AI125940NIGMS NIH HHS R01 GM083204
Abstract
Interleukin-33 (IL-33) is a pleiotropic cytokine that can promote type 2 inflammation but also drives immunoregulation through Foxp3
Indexed as
AnimalsCell MembraneChronic DiseaseDendritic CellsDisease Models, AnimalFemaleHumansImmune ToleranceImmunity, InnateImmunity, MucosalInterleukin-33MaleMembrane ProteinsMiceMice, TransgenicNasal MucosaIL33 protein, humanIl33 protein, mouseInterleukin-33Membrane ProteinsMpeg1 protein, mousePore Forming Cytotoxic Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.