ArticleScience advances2020
A Zic2-regulated switch in a noncanonical Wnt/βcatenin pathway is essential for the formation of bilateral circuits.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator.Nucleic acids research · 2026Article
- Wnt5a regulates the expression of developmental genes in the adult retina following optic nerve crush injury.Histology and histopathology · 2025Article
- ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification.American journal of human genetics · 2024Article
- Proper Frequency of Perinatal Retinal Waves Is Essential for the Precise Wiring of Visual Axons in Nonimage-Forming Nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Development of the Binocular Circuit.Annual review of neuroscience · 2024Review
- Repurposing development genes for axonal regeneration following injury: Examining the roles of Wnt signaling.Frontiers in cell and developmental biology · 2024Review
- Cables1 links Slit/Robo and Wnt/Frizzled signaling in commissural axon guidance.Development (Cambridge, England) · 2023Article
- Neurogenesis redirects β-catenin from adherens junctions to the nucleus to promote axonal growth.Development (Cambridge, England) · 2023Article
- CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism.Neuron · 2023Article
- Multiomic Analysis of Neurons with Divergent Projection Patterns Identifies Novel Regulators of Axon Pathfinding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Transcriptional regulation of neuronal identity.The European journal of neuroscience · 2022Review
- Central nervous system regeneration.Cell · 2022Review
- Transcriptional Control of Axon Guidance at Midline Structures.Frontiers in cell and developmental biology · 2022Review
- Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods.Science (New York, N.Y.) · 2021Article
- Article
- With the Permission of Microtubules: An Updated Overview on Microtubule Function During Axon Pathfinding.Frontiers in molecular neuroscience · 2021Review
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wnt pathway is involved in a wide array of biological processes during development and is deregulated in many pathological scenarios. In neurons, Wnt proteins promote both axon extension and repulsion, but the molecular mechanisms underlying these opposing axonal responses are unknown. Here, we show that Wnt5a is expressed at the optic chiasm midline and promotes the crossing of retinal axons by triggering an alternative Wnt pathway that depends on the accumulation of βcatenin but does not activate the canonical pathway. In ipsilateral neurons, the transcription factor Zic2 switches this alternative Wnt pathway by regulating the expression of a set of Wnt receptors and intracellular proteins. In combination with this alternative Wnt pathway, the asymmetric activation of EphB1 receptors at the midline phosphorylates βcatenin and elicits a repulsive response. This alternative Wnt pathway and its Zic2-triggered switch may operate in other contexts that require a two-way response to Wnt ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.