Evidence map›Paper›PMID 33187759›Full record

Trial reportDrug and alcohol dependence2021

Randomized trial of methadone treatment of arrestees: 24-month post-release outcomes.

Robert P Schwartz, Sharon M Kelly, Shannon G Mitchell, Kevin E O'Grady, Tiffany Duren, Anjalee Sharma, Jan Gryczynski, Jerome H Jaffe

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02334215 (A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail), which is not on this map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02334215 nacompletednot on this map

A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail

TypeinterventionalSponsorFriends Research Institute, Inc.Ran2014 to 2020Enrolled225ConditionsOpioid Use DisorderArmsMethadone, Patient Navigation, Enhanced Treatment as Usual (ETAU)
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Guideline
  2. Management of opioid use disorder: 2024 update to the national clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Guideline
  3. Pooled it
  4. Pooled it
  5. Trial
  6. A self-assessment of opioid use disorder services at a Pacific Northwest County jail.Substance abuse treatment, prevention, and policy · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert P SchwartzFriends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA. Electronic address: rschwartz@friendsresearch.org.
Sharon M KellyFriends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA. Electronic address: skelly@friendsresearch.org.
Shannon G MitchellFriends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA. Electronic address: smitchell@friendsresearch.org.
Kevin E O'GradyDepartment of Psychology, University of Maryland, College Park, College Park, MD, USA. Electronic address: ogrady@umd.edu.
Tiffany DurenFriends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA. Electronic address: tduren@friendsresearch.org.
Anjalee SharmaFriends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA. Electronic address: asharma@friendsresearch.org.
Jan GryczynskiFriends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA. Electronic address: jgryczynski@friendsresearch.org.
Jerome H JaffeFriends Research Institute, 1040 Park Avenue, Suite 103, Baltimore, MD 21201, USA. Electronic address: jhjaffe@aol.com.

Funding

A Randomized Trial of Interim Methadone and Patient Navigation Initiated in JailU01DA013636 · NIDA · FRIENDS RESEARCH INSTITUTE, INC. · PI SCHWARTZ, ROBERT P · 2013 to 2016
$2.4M
NIDA NIH HHS U01 DA013636
6 · The paper itself

Abstract

backgroundWe report on the 24-month post-release outcomes of arrestees with opioid use disorder (OUD) enrolled in a randomized trial comparing three treatment approaches initiated in jail.

methodsAdults (N = 225) receiving medically supervised withdrawal from opioids in the Baltimore Detention Center within a few days of arrest were randomly assigned to: (1) interim methadone treatment plus patient navigation (IM + PN) started in the Detention Center; (2) IM; or (3) Enhanced Treatment-as-Usual (ETAU) consisting of detoxification with methadone and referral to treatment in the community. Participants in both methadone conditions could transfer to standard methadone treatment following release. Participants were interviewed at baseline, and 1, 3, 6, 12, and 24 months post-release. Urine was drug tested at follow-up and official arrest records were obtained.

resultsOn an intention-to-treat basis, there were no significant differences among the three conditions over the 24-month post-release period in terms of opioid- or cocaine-positive urine test results or self-reported opioid or cocaine use, meeting opioid or cocaine use disorder criteria, self-reported criminal behavior, or the number of official arrests. There were 9 fatal overdoses, none occurring during methadone treatment, and 109 hospitalizations unrelated to the study.

conclusionsGiven the high morbidity and mortality found in this population of arrestees and costs to society associated with their health care utilization and continued crime and arrests, research aimed at finding more effective interventions should be continued. CLINICAL

trial registrationClinicalTrials.gov: NCT02334215.

Indexed as

AdultAnalgesics, OpioidBaltimoreCocaine-Related DisordersCosts and Cost AnalysisCrimeDrug OverdoseFemaleHumansMaleMethadoneOpiate Substitution TreatmentOpioid-Related DisordersPatient Acceptance of Health CareAnalgesics, OpioidMethadoneCriminal justiceInterim methadoneJailMethadone treatmentOpioid overdose deathOpioid use disorderPatient navigation

Identifiers

PMID33187759
PMCPMC7750207

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.