Evidence map›Paper›PMID 33187500›Full record

ArticleBMC pediatrics2020

Feature-driven classification reveals potential comorbid subtypes within childhood apraxia of speech.

Catherine M Stein, Penelope Benchek, Gabrielle Miller, Noémi B Hall, Dhanya Menon, Lisa Freebairn, Jessica Tag, Jennell Vick, H Gerry Taylor, Barbara A Lewis and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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  7. Comorbidity and Severity in Childhood Apraxia of Speech: A Retrospective Chart Review.Journal of speech, language, and hearing research : JSLHR · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Catherine M SteinDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, 2103 Cornell Rd, Wolstein Research Building Room 1316, Cleveland, OH, 44106, USA. cmj7@case.edu.ORCID 0000-0002-9763-5023
Penelope BenchekDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, 2103 Cornell Rd, Wolstein Research Building Room 1316, Cleveland, OH, 44106, USA.
Gabrielle MillerDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Noémi B HallDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, 2103 Cornell Rd, Wolstein Research Building Room 1316, Cleveland, OH, 44106, USA.
Dhanya MenonDivision of Public Health, Michigan State University, Lansing, MI, USA.
Lisa FreebairnDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jessica TagDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Jennell VickDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
H Gerry TaylorDepartment of Pediatrics, Case Western Reserve University, and Rainbow Babies & Children's Hospital, University Hospital Case Medical Center, Cleveland, OH, USA.
Barbara A LewisDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Sudha K IyengarDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, 2103 Cornell Rd, Wolstein Research Building Room 1316, Cleveland, OH, 44106, USA.
Case Western Reserve University · USCornell University · USCleveland Hearing & Speech Center · USMichigan State University · USNationwide Children's Hospital · US

Funding

FAMILIAL STUDY OF SEVERE PHONOLOGY DISORDERSR01DC000528 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI LEWIS, BARBARA A · 1995 to 2018
$9.5M
Genetic causes of developmental speech sound disorder in familiesR01DC012380 · NIDCD · CASE WESTERN RESERVE UNIVERSITY · PI IYENGAR, SUDHA K · 2012 to 2016
$3.2M
NIDCD NIH HHS R01 DC000528NIDCD NIH HHS R01 DC012380
6 · The paper itself

Abstract

backgroundChildhood apraxia of speech (CAS) is a neurodevelopmental disorder with heterogeneous communication and other comorbid manifestations. While previous studies have characterized speech deficits associated with CAS, few studies have examined variability in reading and language and/or other developmental comorbidities. We sought to identify comorbid subgroups within CAS that could be clinically relevant as well as genetically distinctive.

methodsIn a group of 31 children with CAS and 8 controls, we performed hierarchical cluster analysis utilizing measures of articulation, vocabulary, and reading. We also conducted a chart review of the children with CAS to examine other clinical characteristics in these children and their association with subgroup membership.

resultsWe identified 3 comorbid subgroups within CAS of varying severity. The high severity subgroup was characterized by poor reading and vocabulary, and the moderate severity subgroup by poor reading and non-word repetition but average vocabulary, compared to the mild severity subgroup. Subgroups were indistinguishable with respect to speech sound production, the hallmark of CAS, all demonstrating poor articulation. Children in the most severe subgroup were more likely to have early problems feeding (p = 0.036).

conclusionsChildren with CAS may potentially be classified into comorbidity groups based on performance on vocabulary and reading measures, providing additional insight into the heterogeneity within CAS with implications for educational interventions.

Indexed as

ApraxiasLanguage Development DisordersChildHumansPhoneticsSpeechSpeech DisordersClinical subtypesCommunication endophenotypesDevelopmental comorbiditiesLanguage impairmentSpeech disorderSpeech severitySpeech-sound disorder

Identifiers

PMID33187500
PMCPMC7664029
OpenAlexW3099191282

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.