ArticleBMC nephrology2020
Age differences in the relationships between risk factors and loss of kidney function: a general population cohort study.
Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Review no. 2: a beginner's guide for calculating eGFR slope using linear mixed-effects model in R-step-by-step methods and code examples.Clinical and experimental nephrology · 2026Review
- Review
- Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications.Cardiovascular diabetology · 2025Observational
- The impact of kidney function on Alzheimer's disease blood biomarkers: implications for predicting amyloid-β positivity.Alzheimer's research & therapy · 2025Article
- Article
- Kidney replacement therapy trends in end-stage kidney disease patients in South Korea during the COVID-19 pandemic.The Korean journal of internal medicine · 2024Article
- Clinical Outcomes in Patients with CKD and Rapid or Non-rapid eGFR Decline: A Report from the DISCOVER CKD Retrospective Cohort.Advances in therapy · 2024Article
- Kidney Impairment in HIV/AIDS Patients Attending Kabutare Level II Teaching Hospital, Southern Province of Rwanda.Rwanda journal of medicine and health sciences · 2024Article
- Prevention of Chronic Kidney Disease and Its Complications in Older Adults.Drugs & aging · 2024Review
- Deterioration of Kidney Function Is Affected by Central Arterial Stiffness in Late Life.Journal of clinical medicine · 2024Article
- Differences in the epidemiology, management and outcomes of kidney disease in men and women.Nature reviews. Nephrology · 2024Review
- Determinants of diabetic nephropathy among adult diabetic patients on follow-up at public hospitals in Addis Ababa, Ethiopia: A case-control study.SAGE open medicine · 2024Article
- Predictors of decline in kidney function in the general population: a decade of follow-up from the Tehran Lipid and Glucose Study.Annals of medicine · 2023Article
- Could the Combination of eGFR and mGPS Facilitate the Differential Diagnosis of Age-Related Renal Decline from Diseases? A Large Study on the Population of Western Sicily.Journal of clinical medicine · 2023Article
- Changes in renal function over time in outpatients with eGFR ≥ 30 mL/min/1.73 mJapanese journal of radiology · 2023Observational
- Article
- High Dietary Phosphorus Is Associated with Increased Breast Cancer Risk in a U.S. Cohort of Middle-Aged Women.Nutrients · 2023Article
- Rethinking Chronic Kidney Disease in the Aging Population.Life (Basel, Switzerland) · 2022Review
- Nomogram to predict rapid kidney function decline in population at risk of cardiovascular disease.BMC nephrology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnnual decline in kidney function is a widely applied surrogate outcome of renal failure. It is important to understand the relationships between known risk factors and the annual decline in estimated glomerular filtration rate (eGFR) according to baseline age; however, these remain unclear.
methodsA community-based retrospective cohort study of adults who underwent annual medical examinations between 1999 and 2013 was conducted. The participants were stratified into different age groups (40-49, 50-59, 60-69, 70-79, and ≥ 80 years) to assess the risk for loss of kidney function. A mixed-effects model was used to estimate the association between risk factors and annual changes in eGFR.
resultsIn total, 51,938 participants were included in the analysis. The age group of ≥80 years included 8127 individuals. The mean annual change in eGFR was - 0.39 (95% confidence interval: - 0.41 to - 0.37) mL/min/1.73 m
conclusionsHigher systolic blood pressure, proteinuria, and smoking were related to faster loss of kidney function, and a greater effect size was observed in the older participants. More risk assessments for older people are required for personalized care.
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