Evidence map›Paper›PMID 33187285›Full record

ArticleViruses2020

Torque Teno Virus Viral Load as a Marker of Immune Function in Allogeneic Haematopoietic Stem Cell Transplantation Recipients.

William Mouton, Anne Conrad, Antonin Bal, Mathilde Boccard, Christophe Malcus, Sophie Ducastelle-Lepretre, Marie Balsat, Fiorenza Barraco, Marie-Virginie Larcher, Gaëlle Fossard and 5 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Review
  6. Review
  7. Anellovirus protein encoded byProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Evaluation of Torquetenovirus (TTV) Particle Integrity Utilizing PMAxx™.International journal of molecular sciences · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Exploring drug resistance genes inFrontiers in microbiology · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

William MoutonJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.ORCID 0000-0002-8455-0952
Anne ConradInternational Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Claude Bernard Lyon 1 University, 69364 Lyon, France.
Antonin BalJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Mathilde BoccardJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Christophe MalcusImmunology Laboratory, Civils Hospices of Lyon, Edouard Herriot Hospital, 69003 Lyon, France.
Sophie Ducastelle-LepretreClinical Haematology Department, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Marie BalsatClinical Haematology Department, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Fiorenza BarracoClinical Haematology Department, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Marie-Virginie LarcherClinical Haematology Department, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Gaëlle FossardClinical Haematology Department, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Hélène Labussière-WalletClinical Haematology Department, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Florence AderInternational Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS Lyon, Claude Bernard Lyon 1 University, 69364 Lyon, France.
Karen Brengel-PesceJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Sophie Trouillet-AssantJoint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Lyon Sud Hospital, 69310 Pierre-Bénite, France.
Lyon Heminf Study Group
Université Claude Bernard Lyon 1 · FRHospices Civils de Lyon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Torque teno virus (TTV) has been proposed as a surrogate biomarker of T-cell function in allogeneic-haematopoietic-stem-cell transplantation (allo-HSCT). Conflicting data exists regarding the value of TTV to assess the degree of immunosuppression. The aim of the present study was to investigate the correlation between TTV viral load and immune function. Using samples from a prospective cohort composed of healthy-volunteers (HV) and allo-HSCT recipients at 6 months post-transplantation, we assessed the correlation between TTV viraemia and immune cell counts or T-cell proliferation capacity post-phytohaemagglutinin stimulation. TTV viraemia was detected in 68% of HV (

Indexed as

Hematopoietic Stem Cell TransplantationImmunosuppression TherapyViral LoadAdultBiomarkersCell ProliferationDNA Virus InfectionsFemaleHumansLeukocytes, MononuclearLymphocyte CountMaleMiddle AgedProspective StudiesTorque teno virusViremiaBiomarkersallogeneic haematopoietic stem cell transplantation (allo-HSCT)biomarkerimmune functional assayimmunocompetencetorque teno virus (TTV)

Identifiers

PMID33187285
PMCPMC7696489
OpenAlexW3103553338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.