Evidence map›Paper›PMID 33187130›Full record

ArticleInternational journal of molecular sciences2020

Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis.

Jiaoyuan Jia, Li Che, Antonio Cigliano, Xue Wang, Graziella Peitta, Junyan Tao, Sheng Zhong, Silvia Ribback, Matthias Evert, Xin Chen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

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  9. Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy.Journal of clinical and translational hepatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Jiaoyuan JiaDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA 94143, USA.
Li CheDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA 94143, USA.
Antonio CiglianoInstitute of Pathology, University of Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-6408-3613
Xue WangDepartment of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA.
Graziella PeittaInstitute of Pathology, University of Regensburg, 93053 Regensburg, Germany.
Junyan TaoDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA 94143, USA.
Sheng ZhongDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA 94143, USA.
Silvia RibbackInstitute of Pathology, University of Greifswald, 17475 Greifswald, Germany.
Matthias EvertInstitute of Pathology, University of Regensburg, 93053 Regensburg, Germany.
Xin ChenDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-9588-0164
Diego F CalvisiDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
University of California, San Francisco · USUniversity of Sassari · ITUniversitätsmedizin Greifswald · DEUniversity of California, Berkeley · USUniversity of Regensburg · DE

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
Associazione Italiana per la Ricerca sul Cancro IG19175Foundation for the National Institutes of Health R01CA221916Liver Center, University of California, San Francisco P30DK026743NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a deadly form of liver malignancy with limited treatment options. Amplification and/or overexpression of

Indexed as

AnimalsApoptosisCarcinogenesisCarcinoma, HepatocellularCell Line, TumorCell ProliferationFatty Acid Synthase, Type IGenes, mycHumansLipogenesisLiver NeoplasmsMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, KnockoutMyeloid Cell Leukemia Sequence 1 ProteinFASN protein, humanFatty Acid Synthase, Type IMechanistic Target of Rapamycin Complex 1MYC protein, humanMyeloid Cell Leukemia Sequence 1 ProteinProto-Oncogene Proteins c-mycRNA, Messengerc-MycFASNhepatocellular carcinomalipogenesismouse models

Identifiers

PMID33187130
PMCPMC7696085
OpenAlexW3103919046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.