ArticleNeuroImage2021
Parallel cortical-brainstem pathways to attentional analgesia.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Effects of pre-procedural video education and intra-procedural virtual reality on anxiety and pain during flexible cystoscopy: a randomized controlled trial.BMC urology · 2026Trial
- Brain network representations of placebo analgesia.Psychological medicine · 2026Article
- Brain mechanisms of pain anticipation in chronic low back pain: Insights into phenotypical responses to mind-body therapy.The journal of pain · 2026Article
- A GABAergic Projection from the Zona Incerta to the Rostral Ventromedial Medulla Modulates Descending Control of Neuropathic Pain.Brain sciences · 2026Article
- A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.Scientific reports · 2025Article
- Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neurocircuitry basis of motor cortex-related analgesia as an emerging approach for chronic pain management.Nature. Mental health · 2024Article
- Simultaneous cortical, subcortical, and brainstem mapping of sensory activation.bioRxiv : the preprint server for biology · 2024Article
- Neural circuits regulating visceral pain.Communications biology · 2024Review
- Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict.Communications biology · 2024Article
- The dual facilitatory and inhibitory effects of social pain on physical pain perception.iScience · 2024Article
- Article
- Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans.Communications biology · 2023Article
- The locus coeruleus input to the rostral ventromedial medulla mediates stress-induced colorectal visceral pain.Acta neuropathologica communications · 2023Article
- Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters.Frontiers in pharmacology · 2023Review
- Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain.Scientific reports · 2022Article
- Thalamocortical Mechanisms for Nostalgia-Induced Analgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- The cAMP Response Element- Binding Protein/Brain-Derived Neurotrophic Factor Pathway in Anterior Cingulate Cortex Regulates Neuropathic Pain and Anxiodepression Like Behaviors in Rats.Frontiers in molecular neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Pain demands attention, yet pain can be reduced by focusing attention elsewhere. The neural processes involved in this robust psychophysical phenomenon, attentional analgesia, are still being defined. Our previous fMRI study linked activity in the brainstem triad of locus coeruleus (LC), rostral ventromedial medulla (RVM) and periaqueductal grey (PAG) with attentional analgesia. Here we identify and model the functional interactions between these regions and the cortex in healthy human subjects (n = 57), who received painful thermal stimuli whilst simultaneously performing a visual attention task. RVM activity encoded pain intensity while contralateral LC activity correlated with attentional analgesia. Psycho-Physiological Interaction analysis and Dynamic Causal Modelling identified two parallel paths between forebrain and brainstem. These connections are modulated by attentional demand: a bidirectional anterior cingulate cortex (ACC) - right-LC loop, and a top-down influence of task on ACC-PAG-RVM. By recruiting discrete brainstem circuits, the ACC is able to modulate nociceptive input to reduce pain in situations of conflicting attentional demand.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.