Evidence map›Paper›PMID 33186619›Full record

ArticleInternational journal of radiation oncology, biology, physics2021

New Data-Driven Gated PET/CT Free of Misregistration Artifacts.

Tinsu Pan, Yang Lu, M Allan Thomas, Zhongxing Liao, Dershan Luo

Open access · greenAbstract readComparative Study
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tinsu PanDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: tpan@mdanderson.org.
Yang LuDepartment of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
M Allan ThomasDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas.
Zhongxing LiaoDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Dershan LuoDepartment of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas.
The University of Texas MD Anderson Cancer Center · US

Funding

Risk prediction and longitudinal assessment of cardiotoxicity and functional capacity trajectory in NSCLC patientsR01HL157273 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIAO, ZHONGXING · 2021 to 2025
$3.8M
Proton Therapy to Reduce Heart Damage for Lung Cancer PatientsR21CA222749 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIAO, ZHONGXING · 2019 to 2020
$388k
Optimization of PET Image Reconstruction for Lesion DetectionR03EB030280 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI GONG, KUANG · 2020 to 2021
$184k
NCI NIH HHS R21 CA222749NHLBI NIH HHS R01 HL157273NIBIB NIH HHS R03 EB030280
6 · The paper itself

Abstract

purposeWe developed a new data-driven gated (DDG) positron emission tomography (PET)/computed tomography (CT) to improve the registration of CT and DDG PET.

methodsWe acquired 10 repeat PET/CT and 35 cine CT scans for the mitigation of misregistration between CT and PET data. We also derived end-expiration phase CT as DDG CT for attenuation correction of DDG PET. Radiation exposure, body mass index (BMI), scan coverage, and effective radiation dose were compared between repeat PET/CT and cine CT. Of the 35 cine CT patients, 14 (capturing 59 total tumors) were compared among average PET/CT (baseline PET attenuation correction by average CT), DDG PET (DDG PET attenuation correction by baseline CT), and DDG PET/CT (DDG PET attenuation correction by DDG CT) for registration and quantification without increasing the scan time for DDG PET.

resultsCompared with repeat PET/CT, cine CT had significantly lower scan coverage (32.5 ± 11.5 cm vs 15.4 ± 4.7 cm; P < .001) and effective radiation dose (3.7 ± 2.6 mSv vs 1.3 ± 0.6 mSv; P < .01). Repeat PET/CT and cine CT did not differ significantly in BMI or radiation exposure (P > .1). Cine CT saved the scan time for not needing a repeat PET. The SUV ratios of average PET/CT, DDG PET, and DDG PET/CT to baseline PET/CT were 1.14 ± 0.28, 1.28 ± 0.20, and 1.63 ± 0.64, respectively (P < .0001), suggesting that the SUV

conclusionOur new DDG PET/CT approach alleviates misregistration artifacts and, compared with DDG PET, improves quantification and registration. The use of cine CT in our DDG PET/CT method also reduces the effective radiation dose and scan coverage compared with repeat CT.

Indexed as

ArtifactsBody Mass IndexData ScienceExhalationFluorodeoxyglucose F18Gallium RadioisotopesHumansLiver NeoplasmsLung NeoplasmsOrgan MotionOrganometallic CompoundsPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiation ExposureRadiotherapy DosageRespiratory MechanicsFluorodeoxyglucose F18gallium Ga 68 dotatateGallium RadioisotopesOrganometallic Compounds

Identifiers

PMID33186619
PMCPMC7965243
OpenAlexW3098236792

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.