ArticleCurrent biology : CB2021
Spatially Distributed Representation of Taste Quality in the Gustatory Insular Cortex of Behaving Mice.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Mapping Fos-immunoreactive neurons activated by intra-oral infusion of quinine, sucrose or water throughout the brain of B6 mice.Brain structure & function · 2026Article
- Sensory and palatability coding of taste stimuli in cortex involves dynamic and asymmetric cortico-amygdalar interactions.Journal of neurophysiology · 2026Article
- Neural coding in gustatory cortex reflects consumption decisions: evidence from conditioned taste aversion.Frontiers in systems neuroscience · 2026Article
- Neuronal architecture of the mouse insular cortex underlying its diverse functions.bioRxiv : the preprint server for biology · 2025Article
- Human spinal cord activation during filling and emptying of the bladder.Nature communications · 2025Article
- Organoid models for chemosensing cell studies.American journal of physiology. Cell physiology · 2025Review
- Direct interoceptive input to the insular cortex shapes learned feeding behavior.bioRxiv : the preprint server for biology · 2025Article
- Retrieval of conditioned immune response in male mice is mediated by an anterior-posterior insula circuit.Nature neuroscience · 2025Article
- Neural Processing of Taste-Related Signals in the Mediodorsal Thalamus of Mice.bioRxiv : the preprint server for biology · 2025Article
- Cortical coding of gustatory and thermal signals in active licking mice.The Journal of physiology · 2025Article
- Effect of taste recall training using 5 sweet substances on sweet taste sensitivities.Chemical senses · 2025Article
- Neuronal Sequences and dynamic coding of water-sucrose categorization in rat gustatory cortices.iScience · 2024Article
- Cortical Coding of Gustatory and Thermal Signals in Active Licking Mice.bioRxiv : the preprint server for biology · 2024Article
- The Insular Cortex: An Interface Between Sensation, Emotion and Cognition.Neuroscience bulletin · 2024Review
- Neural circuits for taste sensation.Molecules and cells · 2024Review
- Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex.Current biology : CB · 2024Article
- Inhibitory Gating of Thalamocortical Inputs onto Rat Gustatory Insular Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Linking emotional valence and anxiety in a mouse insula-amygdala circuit.Nature communications · 2023Article
- Social circuits and their dysfunction in autism spectrum disorder.Molecular psychiatry · 2023Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Visual, auditory, and somatosensory cortices are topographically organized, with neurons responding to similar sensory features clustering in adjacent portions of the cortex. Such topography has not been observed in the piriform cortex, whose responses to odorants are sparsely distributed across the cortex. The spatial organization of taste responses in the gustatory insular cortex (GC) is currently debated, with conflicting evidence from anesthetized rodents pointing to alternative and mutually exclusive models. Here, we rely on calcium imaging to determine how taste and task-related variables are represented in the superficial layers of GC of alert, licking mice. Our data show that the various stimuli evoke sparse responses from a combination of broadly and narrowly tuned neurons. Analysis of the distribution of responses over multiple spatial scales demonstrates that taste representations are distributed across the cortex, with no sign of spatial clustering or topography. Altogether, data presented here support the idea that the representation of taste qualities in GC of alert mice is sparse and distributed, analogous to the representation of odorants in piriform cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.