ArticleCell2020
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells.
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Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 338 papers.
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338citing papers in PubMed
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Who cites it
338 citing papers in PubMed.
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- Developing mouse inhibitory neuron single-cell transcriptomes reveal distinct modes of cell-type diversification.Nature neuroscience · 2026Article
- Mouse to Human Cross-Species Transfer Learning for Electrophysiology-to-Transcriptomics Mapping in Cortical GABAergic Interneurons.Neuroinformatics · 2026Article
- An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.Nature cell biology · 2026Article
- Learning how to experience the world: From circuits to cell types to genes.Current opinion in neurobiology · 2026Review
- Temporal Topology Provides an Interpretable Framework for Neuronal Morphogenesis.Neuroinformatics · 2026Article
- A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan.bioRxiv : the preprint server for biology · 2026Article
- Multimodal atlas of single neuron metabolic electrophysiological coupling uncovers circadian rewiring.iScience · 2026Article
- Synthesizing Mechanistic Hypotheses from Single-Cell Omics via Discretized Feature Attribution and Empirical Language Model Grounding.bioRxiv : the preprint server for biology · 2026Article
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- Multimodal characterization of variation in neuronal types in the mouse basal ganglia.bioRxiv : the preprint server for biology · 2026Article
- SynaptoTagMe, a toolkit for in vivo mapping and modulating neurotransmission at single-cell resolution.eLife · 2026Article
- Neural population dynamics of direct electrical stimulation of neocortex.Cell reports · 2026Article
- In situ graphene-seq: spatial transcriptomics and chronic electrophysiological characterization of tissue microenvironments.Nature communications · 2026Article
- Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state.Nature biotechnology · 2026Article
- Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures.Nature communications · 2026Article
- Cell-type-specific parallel pathways in the canonical cortical microcircuit.bioRxiv : the preprint server for biology · 2026Article
- Deep-learning-assisted simulation of a cortical circuit: integrating anatomy, physiology and function.bioRxiv : the preprint server for biology · 2026Article
278 more citing papers are in PubMed but not listed here.
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Authors and funding
98 authors.
Nathan W GouwensAllen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: nathang@alleninstitute.org.
Staci A SorensenAllen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: stacis@alleninstitute.org.
Fahimeh BaftizadehAllen Institute for Brain Science, Seattle, WA 98109, USA.
Agata BudzilloAllen Institute for Brain Science, Seattle, WA 98109, USA.
Brian R LeeAllen Institute for Brain Science, Seattle, WA 98109, USA.
Tim JarskyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Lauren AlfilerAllen Institute for Brain Science, Seattle, WA 98109, USA.
Katherine BakerAllen Institute for Brain Science, Seattle, WA 98109, USA.
Eliza BarkanAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kyla BerryAllen Institute for Brain Science, Seattle, WA 98109, USA.
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kris BickleyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jasmine BombenAllen Institute for Brain Science, Seattle, WA 98109, USA.
Thomas BraunByte Physics, Schwarzastraße 9, Berlin 12055, Germany.
Krissy BrounerAllen Institute for Brain Science, Seattle, WA 98109, USA.
Tamara CasperAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kirsten CrichtonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA 98109, USA.
Rachel DalleyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Rebecca A de FratesAllen Institute for Brain Science, Seattle, WA 98109, USA.
Nick DeeAllen Institute for Brain Science, Seattle, WA 98109, USA.
Tsega DestaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Samuel Dingman LeeAllen Institute for Brain Science, Seattle, WA 98109, USA.
Nadezhda DotsonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Tom EgdorfAllen Institute for Brain Science, Seattle, WA 98109, USA.
Lauren EllingwoodAllen Institute for Brain Science, Seattle, WA 98109, USA.
Rachel EnstromAllen Institute for Brain Science, Seattle, WA 98109, USA.
Luke EspositoAllen Institute for Brain Science, Seattle, WA 98109, USA.
Colin FarrellAllen Institute for Brain Science, Seattle, WA 98109, USA.
David FengAllen Institute for Brain Science, Seattle, WA 98109, USA.
Olivia FongAllen Institute for Brain Science, Seattle, WA 98109, USA.
Rohan GalaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Clare GamlinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Amanda GaryAllen Institute for Brain Science, Seattle, WA 98109, USA.
Alexandra GlandonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jeff GoldyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Melissa GorhamAllen Institute for Brain Science, Seattle, WA 98109, USA.
Lucas GraybuckAllen Institute for Brain Science, Seattle, WA 98109, USA.
Hong GuAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kristen HadleyAllen Institute for Brain Science, Seattle, WA 98109, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, WA 98109, USA.
Alex M HenryAllen Institute for Brain Science, Seattle, WA 98109, USA.
DiJon HillAllen Institute for Brain Science, Seattle, WA 98109, USA.
Madie HuppAllen Institute for Brain Science, Seattle, WA 98109, USA.
Sara KebedeAllen Institute for Brain Science, Seattle, WA 98109, USA.
Tae Kyung KimAllen Institute for Brain Science, Seattle, WA 98109, USA.
Lisa KimAllen Institute for Brain Science, Seattle, WA 98109, USA.
Matthew KrollAllen Institute for Brain Science, Seattle, WA 98109, USA.
Changkyu LeeAllen Institute for Brain Science, Seattle, WA 98109, USA.
Katherine E LinkAllen Institute for Brain Science, Seattle, WA 98109, USA.
Matthew MalloryAllen Institute for Brain Science, Seattle, WA 98109, USA.
Rusty MannAllen Institute for Brain Science, Seattle, WA 98109, USA.
Michelle MaxwellAllen Institute for Brain Science, Seattle, WA 98109, USA.
Medea McGrawAllen Institute for Brain Science, Seattle, WA 98109, USA.
Delissa McMillenAllen Institute for Brain Science, Seattle, WA 98109, USA.
Alice MukoraAllen Institute for Brain Science, Seattle, WA 98109, USA.
Lindsay NgAllen Institute for Brain Science, Seattle, WA 98109, USA.
Lydia NgAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kiet NgoAllen Institute for Brain Science, Seattle, WA 98109, USA.
Philip R NicovichAllen Institute for Brain Science, Seattle, WA 98109, USA.
Aaron OldreAllen Institute for Brain Science, Seattle, WA 98109, USA.
Daniel ParkAllen Institute for Brain Science, Seattle, WA 98109, USA.
Hanchuan PengAllen Institute for Brain Science, Seattle, WA 98109, USA.
Osnat PennAllen Institute for Brain Science, Seattle, WA 98109, USA.
Thanh PhamAllen Institute for Brain Science, Seattle, WA 98109, USA.
Alice PomAllen Institute for Brain Science, Seattle, WA 98109, USA.
Zoran PopovićCenter for Game Science, Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Lydia PotekhinaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Ramkumar RajanbabuAllen Institute for Brain Science, Seattle, WA 98109, USA.
Shea RansfordAllen Institute for Brain Science, Seattle, WA 98109, USA.
David ReidAllen Institute for Brain Science, Seattle, WA 98109, USA.
Christine RimorinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Miranda RobertsonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kara RonellenfitchAllen Institute for Brain Science, Seattle, WA 98109, USA.
Augustin RuizAllen Institute for Brain Science, Seattle, WA 98109, USA.
David SandmanAllen Institute for Brain Science, Seattle, WA 98109, USA.
Kimberly SmithAllen Institute for Brain Science, Seattle, WA 98109, USA.
Josef SulcAllen Institute for Brain Science, Seattle, WA 98109, USA.
Susan M SunkinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Aaron SzaferAllen Institute for Brain Science, Seattle, WA 98109, USA.
Michael TieuAllen Institute for Brain Science, Seattle, WA 98109, USA.
Amy TorkelsonAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jessica TrinhAllen Institute for Brain Science, Seattle, WA 98109, USA.
Herman TungAllen Institute for Brain Science, Seattle, WA 98109, USA.
Wayne WakemanAllen Institute for Brain Science, Seattle, WA 98109, USA.
Katelyn WardAllen Institute for Brain Science, Seattle, WA 98109, USA.
Grace WilliamsAllen Institute for Brain Science, Seattle, WA 98109, USA.
Zhi ZhouAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jonathan T TingAllen Institute for Brain Science, Seattle, WA 98109, USA.
Anton ArkhipovAllen Institute for Brain Science, Seattle, WA 98109, USA.
Uygar SümbülAllen Institute for Brain Science, Seattle, WA 98109, USA.
Ed S LeinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Christof KochAllen Institute for Brain Science, Seattle, WA 98109, USA.
Zizhen YaoAllen Institute for Brain Science, Seattle, WA 98109, USA.
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA 98109, USA.
Jim BergAllen Institute for Brain Science, Seattle, WA 98109, USA.
Gabe J MurphyAllen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: gabem@alleninstitute.org.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA 98109, USA.
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7MEstablishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1MHigh-throughput robotic analysis of integrated neuronal phenotypesR01EY023173 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., FOREST, CRAIG · 2012 to 2016
$4.3MMozak: Creating an Expert Community to accelerate neuronal reconstruction at scaleR01MH116247 · NIMH · UNIVERSITY OF WASHINGTON · PI POPOVIC, ZORAN · 2018 to 2022
$3.1MNEI NIH HHS R01 EY023173NIMH NIH HHS R01 MH116247NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830
Abstract
Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and reconstructed the local morphologies of 517 of those neurons. We find that most transcriptomic types (t-types) occupy specific laminar positions within visual cortex, and, for most types, the cells mapping to a t-type exhibit consistent electrophysiological and morphological properties. These properties display both discrete and continuous variation among t-types. Through multimodal integrated analysis, we define 28 met-types that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability. We identify layer-specific axon innervation pattern as a defining feature distinguishing different met-types. These met-types represent a unified definition of cortical GABAergic interneuron types, providing a systematic framework to capture existing knowledge and bridge future analyses across different modalities.
Indexed as
Electrophysiological PhenomenaAnimalsCerebral CortexFemaleGABAergic NeuronsGene Expression ProfilingHippocampusIon ChannelsMaleMice, Inbred C57BLNerve Tissue ProteinsTranscriptomeIon ChannelsNerve Tissue ProteinsGABAergic interneuronsmultimodalneuronal cell typeparvalbuminPatch-seqsomatostatintaxonomytranscriptomicsvisual cortex
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