ArticleTransfusion2021
Frequent platelet donation is associated with lymphopenia and risk of infections: A nationwide cohort study.
Article in Transfusion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Potential Health Consequences of Regular Blood Donation: Current Evidence and Remaining Uncertainties.Journal of clinical medicine · 2026Review
- Protection of fundamental human rights by improving patient access to plasma-derived therapies and donor health protection.Vox sanguinis · 2026Review
- Understanding Platelet Donor Experience in Greece: Satisfaction Drivers, Service Gaps, and Implications for Service Design.Journal of patient experience · 2026Article
- Platelet apheresis with additive solution and plasma rinseback affects the cellular composition of LRS chamber products.Scientific reports · 2025Article
- Exploration of the Healthy Donor Effect Among 0.6 Million Blood Donors in China: Longitudinal Study.JMIR public health and surveillance · 2024Article
- Their health is our wealth: lay perceptions on the health impacts of blood donation.Blood transfusion = Trasfusione del sangue · 2024Article
- T-cell lymphopenia in frequent volunteer platelet donors.Hematology. American Society of Hematology. Education Program · 2023Article
- COVID-19 vaccine humoral response in frequent platelet donors with plateletpheresis-associated lymphopenia.Transfusion · 2022Article
- Protecting blood donor health to meet the patient's needs.Blood transfusion = Trasfusione del sangue · 2022Article
- Quantitative restoration of immune defense in old animals determined by naive antigen-specific CD8 T-cell numbers.Aging cell · 2022Article
- Potential Determinants for Radiation-Induced Lymphopenia in Patients With Breast Cancer Using Interpretable Machine Learning Approach.Frontiers in immunology · 2022Article
- Frequent platelet donation is associated with lymphopenia and risk of infections: A nationwide cohort study.Transfusion · 2021Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundRecently, plateletpheresis donations using a widely used leukoreduction system (LRS) chamber have been associated with T-cell lymphopenia. However, clinical health consequences of plateletpheresis-associated lymphopenia are still unknown. STUDY DESIGN AND
methodsA nationwide cohort study using the SCANDAT3-S database was conducted with all platelet- and plasmapheresis donors in Sweden between 1996 and 2017. A Cox proportional hazards model, using donations as time-dependent exposures, was used to assess the risk of infections associated with plateletpheresis donations using an LRS chamber.
resultsA total of 74 408 apheresis donors were included. Among donors with the same donation frequency, plateletpheresis donors using an LRS chamber were at an increased risk of immunosuppression-related infections and common bacterial infections in a dose-dependent manner. While very frequent donors and infections were rare in absolute terms resulting in wide confidence intervals (CIs), the increased risk was significant starting at one-third or less of the allowed donation frequency in a 10-year exposure window, with hazard ratios reaching 10 or more. No plateletpheresis donors that used an LRS chamber experienced a Pneumocystis jirovecii, aspergillus, disseminated mycobacterial, or cryptococcal infection. In a subcohort (n = 42), donations with LRS were associated with low CD4+ T-cell counts (Pearson's R = -0.41; 95% CI, - 0.63 to -0.12).
conclusionFrequent plateletpheresis donation using an LRS chamber was associated with CD4+ T-cell lymphopenia and an increased risk of infections. These findings suggest a need to monitor T-lymphocyte counts in frequent platelet donors and to conduct future investigations of long-term donor health and for regulators to consider steps to mitigate lymphodepletion in donors.
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