On the mechanism of protein supercharging in electrospray ionisation mass spectrometry: Effects on charging of additives with short- and long-chain alkyl constituents with carbonate and sulphite terminal groups.

Eric D B Foley, Muhammad A Zenaidee, Rico F Tabor, Junming Ho, Jonathon E Beves, William A Donald

Open access · hybridAbstract read

In one paragraph

Article in Analytica chimica acta: X, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.5field-weighted citation impact, top 37% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

Native Mass Spectrometry of Soluble Proteins with Sodium Chloride Enabled by a Dendritic Detergent.ACS measurement science au · 2026
Article
Surface Activity of Amines Provides Evidence for the Combined ESI Mechanism of Charge Reduction for Protein Complexes.Analytical chemistry · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Eric D B FoleySchool of Chemistry, University of New South Wales, Sydney, NSW, Australia, 2052.

Muhammad A ZenaideeSchool of Chemistry, University of New South Wales, Sydney, NSW, Australia, 2052.

Rico F TaborSchool of Chemistry, Monash University, Melbourne, VIC, Australia, 3800.

Junming HoSchool of Chemistry, University of New South Wales, Sydney, NSW, Australia, 2052.

Jonathon E BevesSchool of Chemistry, University of New South Wales, Sydney, NSW, Australia, 2052.

William A DonaldSchool of Chemistry, University of New South Wales, Sydney, NSW, Australia, 2052.

UNSW Sydney · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small organic molecules are used as solution additives in electrospray ionisation mass spectrometry (ESI-MS) to increase the charge states of protein ions and improve the performance of intact protein analysis by tandem mass spectrometry. The properties of the additives that are responsible for their charge-enhancing effects (

Indexed as

1,2-butylene carbonate1,2-hexylene carbonate1,2-propylene carbonateChain ejection modelCharge residue modelElectrospray ionisationIon evaporation modelMass spectrometryProtein ionsSupercharging

Identifiers

PMID33186415

DOI10.1016/j.acax.2018.100004

PMCPMC7587038

OpenAlexW2907692003

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.