Evidence map›Paper›PMID 33186408›Full record

Trial reportPloS one2020

Training intensity and improvements in exercise capacity in elderly patients undergoing European cardiac rehabilitation - the EU-CaRE multicenter cohort study.

Thimo Marcin, Prisca Eser, Eva Prescott, Leonie F Prins, Evelien Kolkman, Wendy Bruins, Astrid E van der Velde, Carlos Peña Gil, Marie-Christine Iliou, Diego Ardissino and 5 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 7 countries.

Thimo MarcinCentre for Preventive Cardiology, Sports Medicine, Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-7229-5985
Prisca EserCentre for Preventive Cardiology, Sports Medicine, Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-9734-0682
Eva PrescottDepartment of Cardiology, Bispebjerg Frederiksberg University Hospital, Copenhagen, Denmark.
Leonie F PrinsDiagram B.V., Zwolle, The Netherlands.
Evelien KolkmanDiagram B.V., Zwolle, The Netherlands.
Wendy BruinsIsala Heart Centre, Zwolle, The Netherlands.ORCID 0000-0003-3287-1321
Astrid E van der VeldeIsala Heart Centre, Zwolle, The Netherlands.
Carlos Peña GilDepartment of Cardiology, Complexo Hospitalario Universitario de Santiago de Compostela, SERGAS IDIS CIBERCV, Santiago de Compostela, Spain.
Marie-Christine IliouDepartment of Cardiac Rehabilitation, Assistance Publique Hopitaux de Paris, Paris, France.
Diego ArdissinoDepartment of Cardiology, Parma University Hospital, Parma, Italy.
Uwe ZeymerKlinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany.
Esther P MeindersmaIsala Heart Centre, Zwolle, The Netherlands.
Arnoud W J Van't HofIsala Heart Centre, Zwolle, The Netherlands.
Ed P de KluiverIsala Heart Centre, Zwolle, The Netherlands.
Matthias WilhelmCentre for Preventive Cardiology, Sports Medicine, Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Isala · NLUniversity of Bern · CHDiagram (Netherlands) · NLAssistance Publique – Hôpitaux de Paris · FRCentro de Investigación en Red en Enfermedades Cardiovasculares · ESFrederiksberg Hospital · DKKlinikum Ludwigshafen · DEMaastricht University · NLRadboud University Nijmegen · NLUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGuidelines for exercise intensity prescription in Cardiac Rehabilitation (CR) are inconsistent and have recently been discussed controversially. We aimed (1) to compare training intensities between European CR centres and (2) to assess associations between training intensity and improvement in peak oxygen consumption ([Formula: see text]O2) in elderly CR patients.

methodsPeak [Formula: see text]O2, heart rate and work rate (WR) at the first and second ventilatory thresholds were measured at start of CR. Training heart rate was measured during three sessions spread over the CR. Multivariate models were used to compare training characteristics between centres and to assess the effect of training intensity on change in peak [Formula: see text]O2.

resultsTraining intensity was measured in 1011 out of 1633 EU-CaRE patients in 7 of 8 centers and the first and secondary ventilatory threshold were identified in 1166 and 817 patients, respectively. The first and second ventilatory threshold were found at 44% (SD 16%) and 78% (SD 9%) of peak WR and 78% (SD 9%) and 89% (SD 5%) of peak heart rate, respectively. Training intensity and session duration varied significantly between centres but change in peak [Formula: see text]O2 over CR did not. Training above the first individual threshold (β 0.62, 95% confidence interval [0.25-1.02]) and increase in training volume per hour (β 0.06, 95%CI [0.01-0.12]) were associated with a higher change in peak [Formula: see text]O2.

conclusionWhile training intensity and volume varied greatly amongst current European CR programs, changes in peak [Formula: see text]O2 were similar and the effect of training characteristics on these changes were small.

Indexed as

AgedAged, 80 and overCardiac RehabilitationCohort StudiesEuropeExerciseExercise TestExercise TherapyExercise ToleranceFemaleHeart RateHumansMaleOxygen ConsumptionProspective StudiesPulmonary Gas Exchange

Identifiers

PMID33186408
PMCPMC7665625
OpenAlexW3098626759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.