Evidence map›Paper›PMID 33186355›Full record

Observational studyPloS one2020

Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.

Jean Regina, Matthaios Papadimitriou-Olivgeris, Raphaël Burger, Marie-Annick Le Pogam, Tapio Niemi, Paraskevas Filippidis, Jonathan Tschopp, Florian Desgranges, Benjamin Viala, Eleftheria Kampouri and 11 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 18 pooled it
1.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 18 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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  2. The impact of comorbid allergic airway disease on the severity and mortality of COVID-19: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Jean ReginaService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2219-9834
Matthaios Papadimitriou-OlivgerisService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Raphaël BurgerService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Marie-Annick Le PogamCentre for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-1672-3644
Tapio NiemiCentre for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Paraskevas FilippidisService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Jonathan TschoppService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Florian DesgrangesService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Benjamin VialaService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Eleftheria KampouriService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8019-3073
Laurence RochatService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
David HaefligerService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Mehdi BelkonieneService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Carlos FidalgoService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Antonios KritikosService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Katia JatonInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Laurence SennService of Hospital Preventive Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Pierre-Alexandre BartService of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-7685-8968
Jean-Luc PaganiService of Intensive Care, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Oriol ManuelService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Loïc LhopitallierService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
University of Lausanne · CHCentre universitaire de médecine générale et santé publique, Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.

methodsThis retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.

results145 patients were included in the multivariate model, of whom 36 (24.8%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation with age (OR 1.09 per year, 95% CI 1.03-1.16, p = 0.002), in males (OR 6.99, 95% CI 1.68-29.03, p = 0.007), in patients who presented with a qSOFA score ≥2 (OR 7.24, 95% CI 1.64-32.03, p = 0.009), with bilateral infiltrate (OR 18.92, 3.94-98.23, p<0.001) or with a CRP of 40 mg/l or greater (OR 5.44, 1.18-25.25; p = 0.030) on admission. Patients with more than seven days of symptoms on admission had decreased odds of mechanical ventilation (0.087, 95% CI 0.02-0.38, p = 0.001).

conclusionsThis study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Age, male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation.

Indexed as

AdolescentAdultAgedAged, 80 and overBetacoronavirusCoronavirus InfectionsCOVID-19Electronic Health RecordsFemaleHospitalizationHospitals, UniversityHumansLogistic ModelsMaleMiddle AgedMultivariate Analysis

Identifiers

PMID33186355
PMCPMC7665644
OpenAlexW3025598899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.