Trial reportPloS one2020
Brain MRI findings in relation to clinical characteristics and outcome of tuberculous meningitis.
Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A clinical practice guideline for tuberculous meningitis.The Lancet. Infectious diseases · 2026Guideline
- Review
- Diagnostic Imaging of Extrapulmonary Tuberculosis Across Organ Systems.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical characteristics of childhood tuberculous meningitis and risk factors for severe neurological sequelae disaggregated by age group.BMC infectious diseases · 2026Article
- Neurological complication burden and in-hospital mortality in non-HIV tuberculous meningitis across the lifespan: a retrospective cohort study.Frontiers in medicine · 2026Article
- Construction and verification of early diagnosis model of tuberculous meningitis.Frontiers in cellular and infection microbiology · 2026Article
- Drug-induced liver injury as a strong independent predictor of in-hospital mortality in tuberculous meningitis: potential age-related effect modification suggested in a large lifespan cohort.Frontiers in medicine · 2026Article
- Vestibulocochlear Neuritis as a Paradoxical Reaction in an Immunocompetent Patient with Tuberculous Meningitis.Diagnostics (Basel, Switzerland) · 2025Article
- Anti-TB treatment outcomes in TB meningitis: A systematic review and meta-analysis.New microbes and new infections · 2025Review
- Standardized Infliximab Regimen to Treat Severe Central Nervous System Tuberculosis: A Case Series of 18 Patients.Open forum infectious diseases · 2025Article
- Tuberculous Meningitis Across the Lifespan.The Journal of infectious diseases · 2025Review
- Convolutional neural network using magnetic resonance brain imaging to predict outcome from tuberculosis meningitis.PloS one · 2025Article
- Pediatric Meningeal Diseases: What Radiologists Need to Know.Tomography (Ann Arbor, Mich.) · 2024Review
- Miliary meningeal tuberculosis - an unusual imaging presentation for an early definitive diagnosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Computer-aided prognosis of tuberculous meningitis combining imaging and non-imaging data.Scientific reports · 2024Article
- Occurrence and determinants of seizures and their impact on tuberculous meningitis: a prospective evaluation.Acta neurologica Belgica · 2024Observational
- Predicting cerebral infarction in tuberculous meningitis and its prognostic significance.Biomarkers in medicine · 2024Article
- A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease.Antimicrobial agents and chemotherapy · 2023Article
- Review
- Diagnostic validity of MRI for central nervous system tuberculosis: protocol for a systematic review and meta-analysis.BMJ open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroradiological abnormalities in tuberculous meningitis (TBM) are common, but the exact relationship with clinical and inflammatory markers has not been well established. We performed magnetic resonance imaging (MRI) at baseline and after two months treatment to characterise neuroradiological patterns in a prospective cohort of adult TBM patients in Indonesia. We included 48 TBM patients (median age 30, 52% female, 8% HIV-infected), most of whom had grade II (90%), bacteriologically confirmed (71%) disease, without antituberculotic resistance. Most patients had more than one brain lesion (83%); baseline MRIs showed meningeal enhancement (89%), tuberculomas (77%), brain infarction (60%) and hydrocephalus (56%). We also performed an exploratory analysis associating MRI findings to clinical parameters, response to treatment, paradoxical reactions and survival. The presence of multiple brain lesion was associated with a lower Glasgow Coma Scale and more pronounced motor, lung, and CSF abnormalities (p-value <0.05). After two months, 33/37 patients (89%) showed worsening of MRI findings, mostly consisting of new or enlarged tuberculomas. Baseline and follow-up MRI findings and paradoxical responses showed no association with six-month mortality. Severe TBM is characterized by extensive MRI abnormalities at baseline, and frequent radiological worsening during treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.