Evidence map›Paper›PMID 33186072›Full record

ArticleEnvironmental health perspectives2020

Assessing the Ability of Developmentally Precocious Estrogen Signaling to Recapitulate Ovarian Transcriptomes and Follicle Dynamics in Alligators from a Contaminated Lake.

Matthew D Hale, Benjamin B Parrott

Abstract read
In one paragraph

Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew D HaleSavannah River Ecology Laboratory, Aiken, South Carolina, USA.
Benjamin B ParrottSavannah River Ecology Laboratory, Aiken, South Carolina, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConcern has grown in recent decades over anthropogenic contaminants that interfere with the functioning of endocrine hormones. However, mechanisms connecting developmental processes to pathologies associated with endocrine-disrupting chemical (EDC) exposure are poorly understood in naturally exposed populations.

objectivesWe sought to

methodsAlligators eggs were collected from a contaminated site and a reference site, and a subset of eggs from the reference site were treated with estradiol (

resultsWe observed broad site-of-origin divergence in ovarian transcriptomes and reductions in ovarian follicle density between juvenile alligators from Lake Apopka and the reference site. Treating embryos from the reference site with DISCUSSION: Recapitulation of ovarian abnormalities by precocious

Indexed as

Alligators and CrocodilesAnimalsAnimals, NewbornEmbryonic DevelopmentEmbryo, NonmammalianEndocrine DisruptorsEstradiolEstrogensFemaleFollicle Stimulating HormoneLakesOvarian FollicleOvaryTestosteroneTranscriptomeWater Pollutants, ChemicalEndocrine DisruptorsEstradiolEstrogensFollicle Stimulating HormoneTestosteroneWater Pollutants, Chemical

Identifiers

PMID33186072
PMCPMC7665278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.