Evidence map›Paper›PMID 33185916›Full record

ArticleAngewandte Chemie (International ed. in English)2021

An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt

Eugen Merkul, Joey A Muns, Niels J Sijbrandi, Hendrik-Jan Houthoff, Bart Nijmeijer, Gerro van Rheenen, Jan Reedijk, Guus A M S van Dongen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Antibody-Drug Conjugates-Evolution and Perspectives.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Review
  7. The Chemistry Behind ADCs.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  8. An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtAngewandte Chemie (International ed. in English) · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Eugen MerkulChemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.ORCID 0000-0002-2936-433X
Joey A MunsChemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
Niels J SijbrandiChemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
Hendrik-Jan HouthoffChemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
Bart NijmeijerChemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
Gerro van RheenenChemistry Department, LinXis BV, De Boelelaan 1085c, Amsterdam, 1081, HV, The Netherlands.
Jan ReedijkLeiden Institute of Chemistry, Leiden University, PO Box 9502, 2300, RA, Leiden, The Netherlands.
Guus A M S van DongenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, location VU medical center, Amsterdam, The Netherlands.
LinXis Biopharmaceuticals (Netherlands) · NLAmsterdam University Medical Centers · NLLeiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Pt

Indexed as

AnimalsAntibodies, MonoclonalCell Line, TumorCoordination ComplexesDeferoxamineErb-b2 Receptor Tyrosine KinasesHumansImmunoconjugatesMiceNeoplasmsPlatinumSodium IodideTissue DistributionTransplantation, HeterologousTrastuzumabAntibodies, MonoclonalCoordination ComplexesDeferoxamineERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesImmunoconjugatesPlatinumSodium IodideTrastuzumabantibody-drug conjugatesconjugationlinkersLxplatinum

Identifiers

PMID33185916
PMCPMC7986738
OpenAlexW3098127482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.