Observational studyInternational ophthalmology2021
Optical coherence tomography angiography in juvenile open angle glaucoma: correlation between structure and perfusion.
Observational study in International ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects.Journal of clinical medicine · 2023Article
- Association of Glaucoma with the Risk of Peripheral Arterial Occlusive Disease: A Retrospective Population-Based Cohort Study.Journal of clinical medicine · 2023Article
- Precision (repeatability and reproducibility) of papillary and peripapillary vascular density measurements using optical coherence tomography angiography in children.Frontiers in medicine · 2023Article
- Juvenile-onset open-angle glaucoma - A clinical and genetic update.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeJuvenile open angle glaucoma (JOAG) is a type of glaucoma that occurs in patients younger than 40 years. Only a few studies have assessed vascular perfusion in JOAG and correlated it with structural damage. The aim of this study is to investigate vascular perfusion in JOAG by optical coherence tomography angiography (OCTA) and correlate it with structural damage, represented by retinal nerve fiber layer (RNFL) thinning.
methodsThis is a cross-sectional observational study of 25 eyes of patients with JOAG. All patients underwent full ocular examination and scanning by OCTA to measure parameters such as RNFL thickness, peripapillary and disk vascular density.
resultsAverage superior and inferior RNFL thicknesses were 69.4 (± 22.1) and 70.4 (± 25.6) μm, whereas peripapillary and disk vascular densities were 38.2(± 10), and 39.1(± 12) % and superior and inferior vascular densities were 38.1(± 10.5) and 38.2(± 9.7) %. A strong positive correlation was found between the superior and inferior RNFL thickness and the vascular density of the peripapillary region, the disk and the superior and inferior vascular densities (p < 0.001 for all).
conclusionOCTA parameters are strongly correlated with structural damage in JOAG patients. OCTA can serve as a helpful tool in the diagnosis and assessment of progression in JOAG and be utilized as a prognostic indicator, thus filling the defects and gaps present in other methods of assessment.
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