Evidence map›Paper›PMID 33185796›Full record

ArticleEnvironmental science and pollution research international2021

Lethal and sublethal effects of the natural and healthy spinosad-based formulation Tracer™ on tadpoles of two neotropical species.

Maria Florencia Bahl, Julie Céline Brodeur, Carolina Salgado Costa, María Florencia D'Andrea, Jesica Alejandra Sansiñena, Damián José Marino, Guillermo Sebastián Natale

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Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria Florencia BahlCentro de Investigaciones del Medio Ambiente (CIM), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, Buenos Aires, Argentina.
Julie Céline BrodeurInstituto de Recursos Biológicos, Centro de Investigaciones de Recursos Naturales (CIRN), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina.
Carolina Salgado CostaCentro de Investigaciones del Medio Ambiente (CIM), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, Buenos Aires, Argentina.
María Florencia D'AndreaInstituto de Recursos Biológicos, Centro de Investigaciones de Recursos Naturales (CIRN), Instituto Nacional de Tecnología Agropecuaria (INTA), Hurlingham, Buenos Aires, Argentina.
Jesica Alejandra SansiñenaCentro de Investigaciones del Medio Ambiente (CIM), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, Buenos Aires, Argentina.
Damián José MarinoCentro de Investigaciones del Medio Ambiente (CIM), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, Buenos Aires, Argentina.
Guillermo Sebastián NataleCentro de Investigaciones del Medio Ambiente (CIM), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, Buenos Aires, Argentina. gnatale@quimica.unlp.edu.ar.ORCID http://orcid.org/0000-0001-8895-448X

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas -National Agency of Scientific and Technological Promotion PICT 2015-3137
6 · The paper itself

Abstract

This paper presents the first acute toxicity data of the natural insecticide spinosad in amphibians. The sensitivity of two neotropical sympatric anuran species, Boana pulchella and Rhinella arenarum, to spinosad-based formulation Tracer™ was evaluated. Lethal effects are reported in tadpoles of B. pulchella stage 25 between 2.81 and 35.44 mg spinosad/L, while for the same concentration range no lethal effects were detected in tadpoles of R. arenarum of the same stage. In addition, Tracer™ produced sublethal effects at the individual level on the swimming activity, morphology (growth and presence of abnormalities), and development of B. pulchella from 2.81 to 5.78 mg spinosad/L, while in R. arenarum effects were only detected in the swimming activity and growth from 2.78 and 6.22 mg/L, respectively. At the biochemical level, Tracer™ produced inhibition of different enzymatic activities, among them, catalase activity at 2.81 mg spinosad/L, glutathione S- transferase activity from 2.81 to 2.98 mg spinosad/L, and acetylcholinesterase activity at 2.81 mg spinosad/L. These findings allow us to conclude that B. pulchella is more sensitive than R. arenarum to spinosad-based formulation Tracer™. The effects demonstrated here are not consistent with those expected since spinosad is supposed to be an environmental healthy alternative. This paper provides useful and necessary information to implement regulations on the use of new compounds entering the market and its associated risks.

Indexed as

InsecticidesMacrolidesAnimalsBufo arenarumDrug CombinationsLarvaDrug CombinationsInsecticidesMacrolidesspinosadAnuran species sensitivityBiochemical effectsMorphologyMortalitySpinosadSwimming activityTracer™

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.