SynthesisNeurosurgical review2021
Tumor control and trigeminal dysfunction improvement after stereotactic radiosurgery for trigeminal schwannomas: a systematic review and meta-analysis.
Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Microsurgical Resection vs Stereotactic Radiosurgery for Secondary Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumors: A Systematic Review and Meta-Analysis with Meta-Regression.Neurosurgical review · 2025Pooled it
- Outcomes following surgical resection of trigeminal schwannomas: a systematic review and meta-analysis.Neurosurgical review · 2023Pooled it
- Management of non-vestibular schwannomas in adult patients: a systematic review and consensus statement on behalf of the EANS skull base section Part II: Trigeminal and facial nerve schwannomas (CN V, VII).Acta neurochirurgica · 2022Pooled it
- Efficacy of Gamma Knife radiosurgery in the management of multiple sclerosis-related trigeminal neuralgia: a systematic review and meta-analysis.Neurosurgical review · 2021Pooled it
- Review
- Clinical characteristics, surgical approaches, and outcomes of pediatric trigeminal schwannomas: a case series and literature comparison.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Giant trigeminal schwannoma with cavernous sinus and brainstem involvement: Multimodal imaging and multidisciplinary surgical management.Radiology case reports · 2026Article
- Gamma knife radiosurgery for benign tumor-related trigeminal neuralgia: a single-institution retrospective study.Neurosurgical review · 2025Article
- Management of large Trigeminal Schwannoma: long-term oncologic and functional outcome from a multicentric retrospective cohort.Acta neurochirurgica · 2024Article
- Treating Trigeminal Schwannoma through a Transorbital Approach: A Systematic Review.Journal of clinical medicine · 2024Review
- Preservation of cranial nerve function in large and giant trigeminal schwannoma resection: a case series.Acta neurochirurgica · 2024Article
- Postoperative trigeminal neuropathy outcomes following surgery for tumors involving the trigeminal nerve.Acta neurochirurgica · 2023Observational
- Trigeminal Schwannoma Surgery: Challenges in Preserving Facial Sensation.Advances and technical standards in neurosurgery · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Trigeminal nerve schwannomas (TS) are uncommon intracranial tumors, frequently presenting with debilitating trigeminal and/or oculomotor nerve dysfunction. While surgical resection has been described, its morbidity and mortality rates are non-negligible. Stereotactic radiosurgery (SRS) has emerged with variable results as a valuable alternative. Here, we aimed at reviewing the medical literature on TS treated with SRS so as to investigate rates of tumor control and symptomatic improvement. We reviewed manuscripts published between January 1990 and December 2019 on PubMed. Tumor control and symptomatic improvement rates were evaluated with separate meta-analyses. This meta-analysis included 18 studies comprising a total of 564 patients. Among them, only one reported the outcomes of linear accelerators (Linac), while the others of GK. Tumor control rates after SRS were 92.3% (range 90.1-94.5; p < 0.001), and tumor decrease rates were 62.7% (range 54.3-71, p < 0.001). Tumor progression rates were 9.4% (range 6.8-11.9, p < 0.001). Clinical improvement rates of trigeminal neuralgia were 63.5% (52.9-74.1, p < 0.001) and of oculomotor nerves were 48.2% (range 36-60.5, p < 0.001). Clinical worsening rate was 10.7% (range 7.6-13.8, p < 0.001). Stereotactic radiosurgery for TS is associated with high tumor control rates and favorable clinical outcomes, especially for trigeminal neuralgia and oculomotor nerves. However, patients should be correctly advised about the risk of tumor progression and potential clinical worsening. Future clinical studies should focus on standard reporting of clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.