ArticleHNO2021
[Reducing tinnitus intensity : Pilot study to attenuate tonal tinnitus using individually spectrally optimized near-threshold noise].
Article in HNO, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Phase II Clinical Study on Low-Intensity-Noise Tinnitus Suppression (LINTS) for Tinnitus Treatment.Brain sciences · 2025Article
- Correlation of non-auditory comorbidities and hearing loss in chronic subjective tinnitus patients: a retrospective database study.Frontiers in neurology · 2025Article
- Tinnitus is associated with increased extracellular matrix density in the auditory cortex of Mongolian gerbils.BMC neuroscience · 2024Article
- Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception.Brain : a journal of neurology · 2023Review
- Review
- Preventive Effects of Ginkgo-Extract EGb 761Nutrients · 2022Article
- Circadian Sensitivity of Noise Trauma-Induced Hearing Loss and Tinnitus in Mongolian Gerbils.Frontiers in neuroscience · 2022Article
- Tinnitus is associated with improved cognitive performance and speech perception-Can stochastic resonance explain?Frontiers in aging neuroscience · 2022Article
- Intrinsic Noise Improves Speech Recognition in a Computational Model of the Auditory Pathway.Frontiers in neuroscience · 2022Article
- Spectrally Matched Near-Threshold Noise for Subjective Tinnitus Loudness Attenuation Based on Stochastic Resonance.Frontiers in neuroscience · 2022Article
- Simulated transient hearing loss improves auditory sensitivity.Scientific reports · 2021Article
- Salicylate-Induced Changes in Hearing Thresholds in Mongolian Gerbils Are Correlated With Tinnitus Frequency but Not With Tinnitus Strength.Frontiers in behavioral neuroscience · 2021Article
- Application of New Materials in Auditory Disease Treatment.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAround 15% of the general population is affected by tinnitus, but no real cure exists despite intensive research. Based on our recent causal model for tinnitus development, we here test a new treatment aimed at counteracting the perception. This treatment is based on the stochastic resonance phenomenon at specific auditory system synapses that is induced by externally presented near-threshold noise.
objectiveThis pilot study will investigate whether individually spectrally adapted noise can successfully reduce chronic tonal/narrow-band tinnitus during stimulation. MATERIALS AND
methodsHearing loss (HL) as well as tinnitus pitch (TP) and loudness (TL) were audiometrically measured in 22 adults (46.6±16.3 years; 4 women) with tinnitus. Based on these measurements, up to eight different noise stimuli with five intensities (-20 to +20 dB SL) were generated. These were presented for 40 s each via audiologic headphones in a soundproof chamber. After each presentation, the change in TL was rated on a five-level scale (-2 to +2).
resultsWe found patients (n = 6) without any improvement in their TL perception as well as patients with improvement (n = 16), where stimulation around the TP was most effective. The groups differed in post-hoc analysis of their audiograms: the effectiveness of our new therapeutic strategy obviously depends on the individual HL, and was most effective in normal-hearing tinnitus patients and those with mild HL.
conclusionSubjective TL could be reduced in 16 out of 22 patients during stimulation. For a possible success of a future therapy, the HL seems to be of relevance.
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