SynthesisClinical oral investigations2021
The effect of cetylpyridinium chloride mouthrinse as adjunct to toothbrushing compared to placebo on interproximal plaque and gingival inflammation-a systematic review with meta-analyses.
Synthesis in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Effect of Adjunctive Use of Commercial Daily Mouthwashes on Periodontal Health: An Umbrella Review.Journal of clinical periodontology · 2026Pooled it
- Effectiveness of interdental cleaning devices with active substances: a systematic review.Clinical oral investigations · 2022Pooled it
- Efficacy of regular gargling with a cetylpyridinium chloride plus zinc containing mouthwash can reduce upper respiratory symptoms.PloS one · 2025Trial
- Extending regular oral hygiene reduces the incidence of upper respiratory symptoms.Brazilian oral research · 2025Trial
- Exfoliating effect of β-glycyrrhetinic acid on plaque inducing gingivitis: Comparison with cetylpyridinium chloride.PloS one · 2026Article
- Development of an Antimicrobial Coating Film for Denture Lining Materials.Pharmaceutics · 2025Article
- Antiseptics Prescription for the Prevention and Treatment of Periodontal Diseases: A Comprehensive Review.Health science reports · 2025Article
- Strategies for the prevention of periodontal disease and its impact on general health: Latin America and the Caribbean Consensus 2024.Brazilian oral research · 2024Review
- Effectiveness of New Isomalt-Containing Toothpaste Formulations in Preventing Dental Caries: A Microbial Study.Dentistry journal · 2024Article
- New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry.Molecules (Basel, Switzerland) · 2024Review
- Caries preventing efficacy of new Isomalt-containing mouthrinse formulations: a microbial study.BDJ open · 2024Article
- Formulation and assessment of biological properties of garcinia indica fruit extract mouthrinse as an adjunct to oral hygiene regimen: an in vitro analysis.Journal of applied oral science : revista FOB · 2024Article
- Effectiveness of Mouthwashes in Managing Oral Diseases and Conditions: Do They Have a Role?International dental journal · 2023Article
- Revisiting Oral Antiseptics, Microorganism Targets and Effectiveness.Journal of personalized medicine · 2023Review
- Article
- Preliminary Evaluation of a NitrAdine-Based Brushing Solution for Patients Suffering from Gingivitis: A Prospective Clinical Case-Control Study.European journal of dentistry · 2022Article
- Evidence on the Use of Mouthwash for the Control of Supragingival Biofilm and Its Potential Adverse Effects.Antibiotics (Basel, Switzerland) · 2022Review
- Non-surgical Periodontal Treatment: SRP and Innovative Therapeutic Approaches.Advances in experimental medicine and biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study aimed to systematically review the literature about the interproximal anti-plaque and anti-gingivitis efficacy of cetylpyrydinium chloride (CPC) mouthrinse compared to placebo solution. MATERIALS AND
methodsThree databases (PUBMED, SCOPUS, and EMBASE) were searched for randomized clinical trials that compared the interproximal anti-plaque and anti-gingivitis effect of CPC and placebo mouthrinses as an adjunct to toothbrushing, after a minimum of 6 weeks. Individuals with any periodontal diagnosis were considered. Two meta-analyses were performed for the Turesky modification of the Quigley-Hein plaque index and the Löe and Silness gingival index. For both analyses, the mean differences (MD) between baseline and 6-weeks were calculated using a random-effect model.
resultsEight studies were included. All included studies showed significant improvement in at least one of the parameters, favoring the CPC mouthrinse when compared to placebo. The meta-analysis demonstrated that groups that used CPC displayed a significantly greater reduction in the plaque index score (MD; 95% confidence interval [95%CI]: - 0.70; - 0.83 to - 0.57) and in the gingival index (MD; 95%CI: - 0.38; - 0.47 to - 0.28) when compared to placebo. However, high heterogeneity was observed in both analyses (I
conclusionsWhen considering interproximal surfaces, CPC is efficacious both in plaque and gingival inflammatory parameters, demonstrating the potential to compensate for the limitations of interproximal plaque control. CLINICAL RELEVANCE: CPC may be a good alternative to compensate interproximal plaque removal, improving interproximal gingivitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.