Evidence map›Paper›PMID 33185687›Full record

ArticleBioinformatics (Oxford, England)2021

CGPE: an integrated online server for Cancer Gene and Pathway Exploration.

Jiannan Liu, Chuanpeng Dong, Yunlong Liu, Huanmei Wu

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiannan LiuDepartment of BioHealth Informatics, Indiana University School of Informatics and Computing, Indianapolis, IN 46202, USA.
Chuanpeng DongDepartment of BioHealth Informatics, Indiana University School of Informatics and Computing, Indianapolis, IN 46202, USA.
Yunlong LiuDepartment of Medical and Molecular Genetics, IU School of Medicine, Indianapolis, IN 46202, USA.
Huanmei WuDepartment of BioHealth Informatics, Indiana University School of Informatics and Computing, Indianapolis, IN 46202, USA.

Funding

Structural Biology CoreU54AG065181 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Bruce T Lamb, Alan D. Palkowitz · 2019 to 2026
$61.3M
IUSM Alzheimer's Disease Drug Discovery CenterNIA NIH HHS U54 AG065181NIH HHS # 1U54AG065181-01
6 · The paper itself

Abstract

summaryCancer Gene and Pathway Explorer (CGPE) is developed to guide biological and clinical researchers, especially those with limited informatics and programming skills, performing preliminary cancer-related biomedical research using transcriptional data and publications. CGPE enables three user-friendly online analytical and visualization modules without requiring any local deployment. The GenePub HotIndex applies natural language processing, statistics and association discovery to provide analytical results on gene-specific PubMed publications, including gene-specific research trends, cancer types correlations, top-related genes and the WordCloud of publication profiles. The OnlineGSEA enables Gene Set Enrichment Analysis (GSEA) and results visualizations through an easy-to-follow interface for public or in-house transcriptional datasets, integrating the GSEA algorithm and preprocessed public TCGA and GEO datasets. The preprocessed datasets ensure gene sets analysis with appropriate pathway alternation and gene signatures. The CellLine Search presents evidence-based guidance for cell line selections with combined information on cell line dependency, gene expressions and pathway activity maps, which are valuable knowledge to have before conducting gene-related experiments. In a nutshell, the CGPE webserver provides a user-friendly, visual, intuitive and informative bioinformatics tool that allows biomedical researchers to perform efficient analyses and preliminary studies on in-house and publicly available bioinformatics data. AVAILABILITY AND IMPLEMENTATION: The webserver is freely available online at https://cgpe.soic.iupui.edu. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

NeoplasmsSoftwareAlgorithmsComputersGene ExpressionHumansOncogenes

Identifiers

PMID33185687
PMCPMC8496739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.