Evidence map›Paper›PMID 33185600›Full record

SynthesisJournal of Alzheimer's disease : JAD2020

Paratonia in Dementia: A Systematic Review.

Hans Drenth, Sytse Zuidema, Ivan Bautmans, Lucio Marinelli, Galit Kleiner, Hans Hobbelen

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Paratonia in advanced dementia: Challenges and evidence-based interventions.Canadian family physician Medecin de famille canadien · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Disorders of Movement due to Acquired and Traumatic Brain Injury.Current physical medicine and rehabilitation reports · 2022
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Hans DrenthResearch group Healthy Ageing, Allied Health Care and Nursing, University of Applied Sciences Groningen, Groningen, the Netherlands.
Sytse ZuidemaDepartment of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ivan BautmansFrailty in Ageing Research Group and Gerontology Department, Vrije Universiteit Brussel, Brussels, Belgium.
Lucio MarinelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Galit KleinerDepartment of Medicine, Division of Neurology, University of Toronto, Toronto, ON, Canada.
Hans HobbelenResearch group Healthy Ageing, Allied Health Care and Nursing, University of Applied Sciences Groningen, Groningen, the Netherlands.
University Medical Center Groningen · NLOspedale Policlinico San Martino · ITUniversity of Toronto · CAVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParatonia is a dementia-induced motor abnormality. Although paratonia affects virtually all people with dementia, it is not well known among clinicians and researchers.

objectiveThe aim of this study was to perform a systematic review of the literature on the definition, pathogenesis, diagnosis, and intervention of paratonia as well as to propose a research agenda for paratonia.

methodsIn this systematic review, the Embase, PubMed, CINAHL, and Cochrane CENTRAL databases were searched for articles published prior to December 2019. Two independent reviewers performed data extraction and assessed the risk of bias of the studies. The following data were extracted: first author, year of publication, study design, study population, diagnosis, assessment, pathogenesis, therapy and interventions.

resultsThirty-five studies met the inclusion criteria and were included. Most studies included in the review mention clinical criteria for paratonia. Additionally, pathogenesis, method of assessment, diagnosis, and paratonia severity as are interventions to address paratonia are also discussed.

conclusionThis systematic review outlines what is currently known about paratonia, as well as discusses the preliminary research on the underlying mechanisms of paratonia. Although paratonia has obvious devastating impacts on health and quality of life, the amount of research to date has been limited. In the last decade, there appears to have been increased research on paratonia, which hopefully will increase the momentum to further advance the field.

Indexed as

DementiaDisease ProgressionHumansMuscle HypertoniaMuscle RigidityQuality of LifeDementiamotor disordersmotor skills disordersparatoniasystematic review

Identifiers

PMID33185600
PMCPMC7836054
OpenAlexW3103839999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.