Trial reportJMIR mHealth and uHealth2020
Once Daily Versus Overnight and Symptom Versus Physiological Monitoring to Detect Exacerbations of Chronic Obstructive Pulmonary Disease: Pilot Randomized Controlled Trial.
Trial report in JMIR mHealth and uHealth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03003702 (Domiciliary Monitoring to Predict Exacerbations of COPD), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Domiciliary Monitoring to Predict Exacerbations of COPD
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- AI and Internet of Things for Chronic Obstructive Pulmonary Disease Remote Monitoring: Systematic Review of Exacerbation Prediction and Key Physiological Variables.JMIR medical informatics · 2026Pooled it
- Differentiating the start of an exacerbation from day-to-day variation in people with COPD: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Development of an artificial intelligence prediction model for moderate-to-severe COPD exacerbations using continuous multiple unobtrusive sensors: protocol of a multicentre prospective observational study.BMJ open respiratory research · 2026Article
- Short-term prediction of COPD exacerbations based on wearable vital sign monitoring.PLOS digital health · 2026Article
- Identifying the Challenges in Self-Management and Preferences for Digital Health Technologies Use Among COPD Patients Based on the CeHRes Roadmap: A Formative Qualitative Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Heart rate, respiratory rate and airflow variability differences between stable and exacerbating COPD patients.ERJ open research · 2025Article
- Assessment of Home-based Monitoring in Adults with Chronic Lung Disease: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- The role of digital health in respiratory diseases management: a narrative review of recent literature.Frontiers in medicine · 2025Review
- Unveiling the Influence of AI on Advancements in Respiratory Care: Narrative Review.Interactive journal of medical research · 2024Review
- Validation of the Rome Severity Classification of Chronic Obstructive Pulmonary Disease Exacerbation: A Multicenter Cohort Study.International journal of chronic obstructive pulmonary disease · 2024Article
- Wearable technology interventions in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.NPJ digital medicine · 2023Article
- Evaluating a Remote Monitoring Program for Respiratory Diseases: Prospective Observational Study.JMIR formative research · 2023Article
- Daily allergy burden and heart rate characteristics in adults with allergic rhinitis based on a wearable telemonitoring system.Clinical and translational allergy · 2023Article
- Clinicians' Perspectives of Wearable Technology to Detect and Monitor Exacerbations of Chronic Obstructive Pulmonary Disease: Mixed-Method Survey.International journal of chronic obstructive pulmonary disease · 2023Article
- Trend of Admissions Due to Chronic Lower Respiratory Diseases: An Ecological Study.Healthcare (Basel, Switzerland) · 2022Article
- A proof of concept for continuous, non-invasive, free-living vital signs monitoring to predict readmission following an acute exacerbation of COPD: a prospective cohort study.Respiratory research · 2022Article
- Remote Monitoring for Prediction and Management of Acute Exacerbations in Chronic Obstructive Pulmonary Disease (AECOPD).Life (Basel, Switzerland) · 2022Review
- Application of oxygen saturation variability analysis for the detection of exacerbation in individuals with COPD: A proof-of-concept study.Physiological reports · 2021Article
- Telehealth for patients with interstitial lung diseases (ILD): results of an international survey of clinicians.BMJ open respiratory research · 2021Article
- Remote Assessment of Lung Disease and Impact on Physical and Mental Health (RALPMH): Protocol for a Prospective Observational Study.JMIR research protocols · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarlier detection of chronic obstructive pulmonary disease (COPD) exacerbations may facilitate more rapid treatment with reduced risk of hospitalization. Changes in pulse oximetry may permit early detection of exacerbations. We hypothesized that overnight pulse oximetry would be superior to once-daily monitoring for the early detection of exacerbations.
objectiveThis study aims to evaluate whether measuring changes in heart rate and oxygen saturation overnight is superior to once-daily monitoring of both parameters and to assess symptom changes in facilitating earlier detection of COPD exacerbations.
methodsA total of 83 patients with COPD were randomized to once-daily or overnight pulse oximetry. Both groups completed the COPD assessment test questionnaire daily. The baseline mean and SD for each pulse oximetry variable were calculated from 14 days of stable monitoring. Changes in exacerbation were expressed as Z scores from this baseline.
resultsThe mean age of the patients was 70.6 (SD 8.1) years, 52% (43/83) were female, and the mean FEV1 was 53.0% (SD 18.5%) predicted. Of the 83 patients, 27 experienced an exacerbation. Symptoms were significantly elevated above baseline from 5 days before to 12 days after treatment initiation. Day-to-day variation in pulse oximetry during the stable state was significantly less in the overnight group than in the once-daily group. There were greater relative changes at exacerbation in heart rate than oxygen saturation. An overnight composite score of change in heart rate and oxygen saturation changed significantly from 7 days before initiation of treatment for exacerbation and had a positive predictive value for exacerbation of 91.2%. However, this was not statistically better than examining changes in symptoms alone.
conclusionsOvernight pulse oximetry permits earlier detection of COPD exacerbations compared with once-daily monitoring. Monitoring physiological variables was not superior to monitoring symptoms, and the latter would be a simpler approach, except where there is a need for objective verification of exacerbations.
trial registrationClinicalTrials.gov NCT03003702; https://clinicaltrials.gov/ct2/show/NCT03003702.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.