ArticleCirculation2021
Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients With Cardiometabolic Disease.
Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Pooled it
- Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial.Cardiovascular research · 2023Trial
- Next-Generation Stroke Biomarkers: Bridging the Gap Between Innovation and Translation.Journal of clinical medicine · 2026Review
- Improving Polygenic Risk Prediction for Atherosclerotic Cardiovascular Disease in East Asian Populations.JACC. Asia · 2026Review
- Vitamin D Receptor (VDR) Polymorphisms and Cardiometabolic Profiles in Orthopedic Patients: A Cluster-Based Analysis.International journal of molecular sciences · 2026Article
- Restricted Versus Genome-Wide Genetic Risk Scores for Coronary Artery Disease.Journal of the American Heart Association · 2026Article
- Article
- Proinflammatory Risk Factors in Patients with Ischemic Stroke: A Systematic Review and Meta-Analysis.Antioxidants (Basel, Switzerland) · 2025Review
- Common genetic variants nearmedRxiv : the preprint server for health sciences · 2025Article
- Global, regional and national burden of stroke and subtypes burden in women of reproductive age: insights based on Global Burden of Disease 2021.BMC public health · 2025Article
- Genetic Risk and Prognosis of the First Incident Stroke Survivors: Findings from China Kadoorie Biobank and UK Biobank.Neurology · 2025Article
- MetaGeno: a chromosome-wise multi-task genomic framework for ischaemic stroke risk prediction.Briefings in bioinformatics · 2025Article
- Polygenic prediction for underrepresented populations through transfer learning by utilizing genetic similarity shared with European populations.Briefings in bioinformatics · 2024Article
- Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese.Stroke and vascular neurology · 2024Article
- European and US Guideline-Based Statin Eligibility, Genetically Predicted Coronary Artery Disease, and the Risk of Major Coronary Events.Journal of the American Heart Association · 2024Article
- Assessing the individual risk of stroke in caregivers of patients with stroke.Arquivos de neuro-psiquiatria · 2024Article
- Clinical use of polygenic risk scores for detection of peripheral artery disease and cardiovascular events.PloS one · 2024Article
- Genome-wide association studies of ischemic stroke based on interpretable machine learning.PeerJ. Computer science · 2024Article
- Association between genetic predisposition and disease burden of stroke in China: a genetic epidemiological study.The Lancet regional health. Western Pacific · 2023Article
- Integrating polygenic and clinical risks to improve stroke risk stratification in prospective Chinese cohorts.Science China. Life sciences · 2023Article
Corrections and comments
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Authors and funding
28 authors at 11 institutions in 8 countries.
Funding
Abstract
backgroundGenome-wide association studies have identified single-nucleotide polymorphisms that are associated with an increased risk of stroke. We sought to determine whether a genetic risk score (GRS) could identify subjects at higher risk for ischemic stroke after accounting for traditional clinical risk factors in 5 trials across the spectrum of cardiometabolic disease.
methodsSubjects who had consented for genetic testing and who were of European ancestry from the ENGAGE AF-TIMI 48 (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation), SOLID-TIMI 52 (Stabilization of Plaques Using Darapladib), SAVOR-TIMI 53 (Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus), PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin), and FOURIER (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Patients With Elevated Risk) trials were included in this analysis. A set of 32 single-nucleotide polymorphisms associated with ischemic stroke was used to calculate a GRS in each patient and identify tertiles of genetic risk. A Cox model was used to calculate hazard ratios for ischemic stroke across genetic risk groups, adjusted for clinical risk factors.
resultsIn 51 288 subjects across the 5 trials, a total of 960 subjects had an ischemic stroke over a median follow-up period of 2.5 years. After adjusting for clinical risk factors, a higher GRS was strongly and independently associated with increased risk for ischemic stroke (
conclusionsAcross a broad spectrum of subjects with cardiometabolic disease, a 32-single-nucleotide polymorphism GRS was a strong, independent predictor of ischemic stroke. In patients with atrial fibrillation but lower CHA
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